Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Textbook Question
Chapter 8, Problem 6RQ
Match the bones listed in column B to their descriptions in column A. Answers in column B may be used more than once.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 8 Solutions
Human Anatomy
Ch. 8 - Which part of the scapula articulates with the...Ch. 8 - How is the pectoral girdle attached to the axial...Ch. 8 - Name the three fossae of the scapula, and describe...Ch. 8 - Prob. 4CYUCh. 8 - For each of the features listed, identify (a) the...Ch. 8 - Prob. 6CYUCh. 8 - Name the bones that are located in the palm of the...Ch. 8 - Prob. 8CYUCh. 8 - Name the specific part of the hip bone that bears...Ch. 8 - When you place your hands on your "hips," what...
Ch. 8 - Prob. 11CYUCh. 8 - What specific feature of the hip bone articulates...Ch. 8 - What structures form the two bony� bumps" on...Ch. 8 - On which bone is each of the following features...Ch. 8 - What is the keystone of the medial longitudinal...Ch. 8 - In males, what changes in the skeleton occur at...Ch. 8 - Considering what you know about how the hip bones...Ch. 8 - Prob. 1RQCh. 8 - Prob. 2RQCh. 8 - Prob. 3RQCh. 8 - The greater and lesser tubercles are located on...Ch. 8 - The lateral malleolus is the (a) proximal portion...Ch. 8 - Match the bones listed in column B to their...Ch. 8 - Match the bones in column B to their descriptions...Ch. 8 - From the list of bones given, indicate all those...Ch. 8 - 1n the forearm, the radius is the bone;...Ch. 8 - The scaphoid and lunate articulate with the (a)...Ch. 8 - The major function of the pectoral girdle is...Ch. 8 - List three differences between the male and female...Ch. 8 - Describe the function of the arches of the root.Ch. 8 - Prob. 14RQCh. 8 - Define and distinguish the true pelvis from the...Ch. 8 - Lance was a bright anatomy student, but he...Ch. 8 - Draw the scapula in posterior view, and label all...Ch. 8 - Describe the location of each of the following...Ch. 8 - (a) Which body regions do anatomists call the arm...Ch. 8 - Torn Williams, a teaching assistant in anatomy...Ch. 8 - Name all the bones of the appendicular skeleton...Ch. 8 - The hand and foot are structurally similar in many...Ch. 8 - Malcolm injured himself after trying to break his...Ch. 8 - Prob. 2CRCAQCh. 8 - Prob. 3CRCAQCh. 8 - Prob. 4CRCAQCh. 8 - The most common bone fracture in people under 75...
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