EBK HUMAN PHYSIOLOGY
15th Edition
ISBN: 9781260163049
Author: Fox
Publisher: MCGRAW HILL BOOK COMPANY
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Textbook Question
Chapter 8, Problem 18RA
The thalamus has been described as a "switchboard." Explain why, by describing the pathway of somatic sensory information from the receptors to the cerebral cortex.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 8 Solutions
EBK HUMAN PHYSIOLOGY
Ch. 8 - Prob. 1CPCh. 8 - Describe the embryonic origin of the brain...Ch. 8 - Prob. 3aCPCh. 8 - Describe the locations and functions of the basal...Ch. 8 - Prob. 4aCPCh. 8 - Prob. 4bCPCh. 8 - Prob. 5CPCh. 8 - Prob. 6CPCh. 8 - Prob. 7aCPCh. 8 - Prob. 7bCP
Ch. 8 - Prob. 8aCPCh. 8 - Prob. 8bCPCh. 8 - Prob. 9CPCh. 8 - Prob. 10CPCh. 8 - Prob. 11aCPCh. 8 - List the tracts of the extrapyramidal system and...Ch. 8 - Prob. 12aCPCh. 8 - Prob. 12bCPCh. 8 - Prob. 1RACh. 8 - Prob. 2RACh. 8 - Prob. 3RACh. 8 - Prob. 4RACh. 8 - Prob. 5RACh. 8 - Prob. 6RACh. 8 - Prob. 7RACh. 8 - Prob. 8RACh. 8 - Prob. 9RACh. 8 - Prob. 10RACh. 8 - Prob. 11RACh. 8 - Prob. 12RACh. 8 - Prob. 13RACh. 8 - Prob. 14RACh. 8 - Prob. 15RACh. 8 - Prob. 16RACh. 8 - Prob. 17RACh. 8 - The thalamus has been described as a...Ch. 8 - Prob. 19RACh. 8 - Prob. 20RACh. 8 - Prob. 21RACh. 8 - Prob. 22RACh. 8 - Prob. 23RACh. 8 - Prob. 24RACh. 8 - State two reasons why researchers distinguish...Ch. 8 - Describe evidence showing that the hippocampus is...Ch. 8 - Prob. 27RACh. 8 - Prob. 28RACh. 8 - Prob. 29RACh. 8 - Recent studies suggest that medial temporal lobe...Ch. 8 - Much has been made (particularly by left-handers)...Ch. 8 - Prob. 32RACh. 8 - Prob. 33RACh. 8 - Neurologists have noticed that patients with...Ch. 8 - Prob. 35RACh. 8 - Prob. 36RACh. 8 - Table 7.3 (chapter 7) provides the axon diameters...Ch. 8 - Prob. 38RACh. 8 - Prob. 39RACh. 8 - Table 7.3 (chapter 7) provides the axon diameters...
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