CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
8th Edition
ISBN: 9781259880193
Author: SALADIN
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 7, Problem 8BYMV
Summary Introduction
To build your medical vocabulary:
-physis
Meaning of the word element:
Growth
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 7 Solutions
CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
Ch. 7.1 - Name at least five tissues found in a boneCh. 7.1 - Prob. 2BYGOCh. 7.1 - Prob. 3BYGOCh. 7.1 - Prob. 4BYGOCh. 7.1 - The branch of medicine and biology that deals with...Ch. 7.1 - Prob. 2AYLOCh. 7.1 - Prob. 3AYLOCh. 7.1 - Prob. 4AYLOCh. 7.1 - Prob. 5AYLOCh. 7.1 - Other anatomical features of a long bone including...
Ch. 7.1 - Prob. 7AYLOCh. 7.2 - Suppose you had unlabeled electron micrographs of...Ch. 7.2 - Name three organic components of the bone matrix.Ch. 7.2 - What are the mineral crystals of bone called, and...Ch. 7.2 - Sketch a cross section of an osteon and label its...Ch. 7.2 - Prob. 9BYGOCh. 7.2 - Histology of Osseous Tissue 1. The four cell type...Ch. 7.2 - Organic and inorganic components of the bone...Ch. 7.2 - Osteon structure and the relationship of osteonic...Ch. 7.2 - The route by which nerves and blood vessels...Ch. 7.2 - Prob. 5AYLOCh. 7.2 - Prob. 6AYLOCh. 7.3 - Describe the stages of intramembranous...Ch. 7.3 - Describe how a cartilage model is transformed into...Ch. 7.3 - Prob. 12BYGOCh. 7.3 - Prob. 13BYGOCh. 7.3 - Stages of intramembranous ossification; some bones...Ch. 7.3 - Prob. 2AYLOCh. 7.3 - Prob. 3AYLOCh. 7.3 - How stresses on bones remodel item throughout...Ch. 7.4 - Prob. 14BYGOCh. 7.4 - Prob. 15BYGOCh. 7.4 - Prob. 16BYGOCh. 7.4 - Prob. 17BYGOCh. 7.4 - Prob. 1AYLOCh. 7.4 - Prob. 2AYLOCh. 7.4 - Prob. 3AYLOCh. 7.4 - The role of the skeleton as a calcium reservoir in...Ch. 7.4 - Prob. 5AYLOCh. 7.4 - Prob. 6AYLOCh. 7.4 - Prob. 7AYLOCh. 7.4 - Prob. 8AYLOCh. 7.4 - Prob. 9AYLOCh. 7.4 - Prob. 10AYLOCh. 7.5 - Prob. 18BYGOCh. 7.5 - Prob. 19BYGOCh. 7.5 - Prob. 20BYGOCh. 7.5 - Prob. 1AYLOCh. 7.5 - Causes of osteoporosis: its risk factor,...Ch. 7 - Which cells have a ruffled border and secrete...Ch. 7 - Prob. 2TYRCh. 7 - Prob. 3TYRCh. 7 - Osteoclasts are most closely related, by common...Ch. 7 - The walls between cartilage lacunae break down in...Ch. 7 - Which of these is not an effect of PTH? a. rise in...Ch. 7 - Prob. 7TYRCh. 7 - One long bone meets another at its a. diaphysis....Ch. 7 - Calcitriol is made from a. calcitonin. b....Ch. 7 - One sign of osteoporosis is a. osteosarcoma. b....Ch. 7 - Calcium phosphate crystallizes in bone as a...Ch. 7 - Prob. 12TYRCh. 7 - Prob. 13TYRCh. 7 - Prob. 14TYRCh. 7 - Prob. 15TYRCh. 7 - Prob. 16TYRCh. 7 - Prob. 17TYRCh. 7 - Prob. 18TYRCh. 7 - Prob. 19TYRCh. 7 - Prob. 20TYRCh. 7 - Prob. 1BYMVCh. 7 - Prob. 2BYMVCh. 7 - Prob. 3BYMVCh. 7 - Prob. 4BYMVCh. 7 - ortho-Ch. 7 - Prob. 6BYMVCh. 7 - Prob. 7BYMVCh. 7 - Prob. 8BYMVCh. 7 - spic-Ch. 7 - topo-Ch. 7 - Prob. 1WWTSCh. 7 - Prob. 2WWTSCh. 7 - Prob. 3WWTSCh. 7 - The growth zone of the lone bones of adolescents...Ch. 7 - Prob. 5WWTSCh. 7 - Prob. 6WWTSCh. 7 - Whats Wrong with These Statements? 7. The protein...Ch. 7 - Prob. 8WWTSCh. 7 - Prob. 9WWTSCh. 7 - Prob. 10WWTSCh. 7 - Most osteocytes of an osteon are far removed from...Ch. 7 - Prob. 2TYCCh. 7 - How does the regulation of blood calcium...Ch. 7 - Describe how the arrangement of trabeculae in...Ch. 7 - Identify two bone diseases you would expect to see...
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