The Complete Textbook of Phlebotomy
5th Edition
ISBN: 9781337514767
Author: Hoeltke, Lynn B.
Publisher: Cengage Learning
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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-
expressed in normal cells?
a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function
b. mutant Grb2 protein that cannot bind to RTK
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d. mutant PDK that has the PH domain but lost the kinase function
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