The Immune System, 4th Edition
The Immune System, 4th Edition
4th Edition
ISBN: 9780815344667
Author: Peter Parham
Publisher: W. W. Norton & Company
bartleby

Concept explainers

bartleby

Videos

Question
Book Icon
Chapter 7, Problem 1Q
Summary Introduction

Introduction:

T lymphocyteor T-cell is (white blood cellsubtype) a form of lymphocyte whichdoes a central part in (cell-mediated) immunity. Due to the existence of T-cell receptor on the surface of cell these cells can be differentiated from other lymphocytes likenatural killer cells and B cells.

Expert Solution & Answer
Check Mark

Answer to Problem 1Q

Correct answer:

The correct answer is option (c) bone marrow→thymus → lymph nodes.

Explanation of Solution

Explanation/justification for the correct answer:

Option (c) bone marrow → thymus → lymph nodes. The development of T-cells takes place in the bone marrow from theHematopoietic Stem Cells but commonly their differentiation happens in the thymus. These cells enter the cortexregion of thymus and they migrate to thymic medulla for further differentiation. Mature T-cells (at the thymic medulla) are then liberated into the peripheral circulation. So, the correct answer is option (c).

Explanation for incorrect answer:

Option (a) Thymus → bone marrow → spleen. Development of T-cells takes place from bone marrow region to thymus and is completed in lymph nodes and no spleen is involved. So, this is an incorrect option.

Option (b) Thymus → bone marrow → thymus. The bone marrow is the initial tissue in which the developmental pathway of T cells begins. So, this is an incorrect answer.

Option (d) Lymph nodes → thymus → spleen. Lymph nodes is the final stage in the developmental pathway of T cells. So, this is an incorrect answer.

Option (e) Bone marrow → lymph nodes → thymus. The option shows the starting point of pathway of T-cells development. So, this is an incorrect answer.

Conclusion

Hence, in the bone marrow T-cells initiate and in thymus these mature and differentiate into different subtypes. The correct answer is option (c) bone marrow → thymus → lymph nodes.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!
Students have asked these similar questions
19. On the diagram below a. Label the three pictures as: DNA; polypeptide; or RNA. b. Label the arrows as: translation or transcription/RNA processing. c. Add the following details to the diagram. Promoter region TATA box Transcription start site Transcription terminator Intron (A,B,C,D) Exons (1,2,3,4,5) Splice sites 5' cap 5' UTR (untranslated region) 3' poly A tail 3' UTR (untranslated region) Translational start (AUG) Translational stop (UGA, UAG, or UAA) N and C ends of polypeptide 0000
Match the letter labels in the figure below to the terms. Some letter labels are not used. MNNNNNNIN M C B A M D F E H K G 8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions. 1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction? 2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe: a) What molecule do you recommend for the trial. Why? b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?  3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale. 4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale. Mutation 1 Mutation 2
Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:PEARSON
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Anatomy & Physiology
Biology
ISBN:9781259398629
Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:Mcgraw Hill Education,
Text book image
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:9780815344322
Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:W. W. Norton & Company
Text book image
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:9781260159363
Author:Martin, Terry R., Prentice-craver, Cynthia
Publisher:McGraw-Hill Publishing Co.
Text book image
Inquiry Into Life (16th Edition)
Biology
ISBN:9781260231700
Author:Sylvia S. Mader, Michael Windelspecht
Publisher:McGraw Hill Education
Immune System and Immune Response Animation; Author: Medical Sciences Animations;https://www.youtube.com/watch?v=JDdbUBXPKc4;License: Standard YouTube License, CC-BY
Immune response: summary; Author: Dr Bhavsar Biology;https://www.youtube.com/watch?v=ADANgHkX4OY;License: Standard Youtube License