Human Heredity: Principles and Issues
Human Heredity: Principles and Issues
11th Edition
ISBN: 9781305683952
Author: Michael Cummings
Publisher: Cengage Learning US
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Chapter 7, Problem 16QP
Summary Introduction

To determine: The reason which makes calico cats almost invariably female.

Introduction: Females have two X chromosomes due to which they have two copies of all the genes present on that chromosome whereas males carry only one copy of X chromosome due to which they have only one copy of the gene present on that chromosome. All female mammals contain a genetically inactive X chromosome which is known as the Barr body. The expression of gene products by the genes present on the X chromosome is equalized in both males and the females.

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Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences  A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?
Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY