Prescott's Microbiology
11th Edition
ISBN: 9781260211887
Author: WILLEY, Sandman, Wood
Publisher: McGraw Hill
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Textbook Question
Chapter 6.4, Problem 1.2CC
What advantages might a phage gain by being capable of lysogeny?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
3.
In the tomato, red fruit (O+) is dominant over orange fruit (0), and yellow flowers (W+) are dominant over white
flowers (w). A cross was made between true-breeding plants with red fruit and yellow flowers, and plants with
orange fruit and white flowers. The F₁ plants were then crossed to plants with orange fruit and white flowers, which
produced the following results:
a.
b.
333 red fruit, yellow flowers
64 red fruit, white flowers
58 orange fruit, yellow flowers
350 orange fruit, white flowers
Conduct a chi-square analysis to demonstrate that these two genes DO NOT assort independently. Make sure
to interpret the P value obtained from your chi-square test.
Calculate and provide the map distance (in map units) between the two genes.
Chapter 6 Solutions
Prescott's Microbiology
Ch. 6.2 - MICRO INQUIRY Which capsids are icosahedral? Which...Ch. 6.2 - Prob. 2MICh. 6.2 - MICRO INQUIRY Why is T4 said to have binal...Ch. 6.2 - Retrieve, Infer, Apply 1. How are viruses similar...Ch. 6.2 - Retrieve, Infer, Apply 2. What is the difference...Ch. 6.2 - Retrieve, Infer, Apply 3. Compare the structure of...Ch. 6.2 - Prob. 4CCCh. 6.2 - Retrieve, Infer, Apply 5. All four nucleic acid...Ch. 6.3 - MICRO INQUIRY Which of these mechanisms involves...Ch. 6.3 - MICRO INQUIRY Why do the empty capsids remain...
Ch. 6.3 - Explain why the receptors that viruses have...Ch. 6.3 - What probably plays the most important role in...Ch. 6.3 - How do you think the complexity of the viral...Ch. 6.3 - In general, DNA viruses can be much more dependent...Ch. 6.3 - Consider the origin of viral envelopes and suggest...Ch. 6.3 - Why are the proteins involved in virion assembly...Ch. 6.4 - Why is a lysogen considered a new or different...Ch. 6.4 - Define the terms lysogeny, temperate phage,...Ch. 6.4 - What advantages might a phage gain by being...Ch. 6.4 - Describe lysogenic conversion and its...Ch. 6.4 - How does a latent infection differ from a chronic...Ch. 6.4 - What is a cytocidal infection? What is a...Ch. 6.4 - Define the following terms: tumor, neoplasia,...Ch. 6.4 - Distinguish the mechanism by which dsDNA viruses...Ch. 6.5 - Prob. 1MICh. 6.5 - Prob. 1CCCh. 6.5 - Given that viruses must be cultivated to make...Ch. 6.7 - What are viroids and why are they of great...Ch. 6.7 - How does a viroid differ from a virus? From a...Ch. 6.7 - What is a prion? In what way does a prion differ...Ch. 6.7 - Prob. 4CCCh. 6 - Prob. 1RCCh. 6 - Prob. 2RCCh. 6 - Many classification schemes are used to identify...Ch. 6 - The origin and evolution of viruses is...Ch. 6 - Consider the separate stages of an animal virus...
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