HUMAN BIOLOGY W/ACCESS
HUMAN BIOLOGY W/ACCESS
16th Edition
ISBN: 9781260997231
Author: Mader
Publisher: MCG
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Chapter 6, Problem 8A
Summary Introduction

Introduction:

White blood cells are formed elements present in blood cells. They are defense cells in human body. There are two forms of WBCs: granular or agranular, which are distinct on basis of presence of granules or absence of granules.

The agranular leukocytes have no granules in their cytoplasm and have one lobed nucleus. They are basically two types: lymphocytes or monocytes. Since, they are agranular they did not take any stain and appear as colorless.

Lymphocytes or monocytes both provide immunity to the cells and prevent the cell from the infection.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
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