Chapter 6, Problem 26R

Formation and dissolution of clots is primarily regulated by   hemolysis positive feedback negative feedback thrombopoiesis

Thrombocytopenia (throm-bo-sye-tow-pee-ne-ah) is a disorder that develops when certain drugs, bone marrow cancer, or radiation destroys red bone marrow, including stem cells that give rise to platelets. Predict a likely symptom of this disorder.

The right lymphatic duct drains the lymph from: the entire right side of the body only the right side of the head and neck and right upper limb O the right side of the thorax, right upper limb, and right side of the head and neck only the right side of the thorax the right side of the thorax, the abdomen, and the right lower and the right upper limbs

Story on hemophilia   Part I. The family story   Olivia, a blond teen, is resoundingly beating her male tennis opponent, Ned.  She is new in town and jokes that her partner went easy on her to make her feel welcome.  From nowhere, a tennis ball cuts across their court.  The dark-eyed brunette who hit it, Diana, stares at them.  Olivia seems stunned into silence.  Diana sneers at her and says, “Any day now.”  Olivia hits the ball back to her, almost directly into her face.               “What was that all about? You know Diana Morrison?” Ned asks.               “I used to, back when I lived in Granville the first time,” Olivia answers. “Back then we were friends. It was like a million years ago.” As they walk away, we hear Diana’s tennis coach screaming, “Diana, Diana! Somebody help Diana, please!”               “Is she OK?  What’s happened?” Olivia gasps after running over. Diana has collapsed to the tennis court, not breathing.               “She just dropped unexpectedly,” Diana’s…

Describe any 3 types of leukocytes (name, functions, and characteristics) and indicates which one is/are granulocytes or agranulocytes.

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia.   Discussion Questions Discuss how the gastric abnormalities contribute to vitamin B12 and iron deficiency and how vitamin B12 deficiency causes complications associated with pernicious anemia. (See Pernicious Anemia—Pathophysiology, Etiology.)

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discussion Questions Discuss other tests that could be performed to diagnose this type of anemia. (See Pernicious Anemia—Diagnostic Tests.)

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia.   Discussion Questions Discuss the treatment available and the limitations.

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discussion Questions Relate the pathophysiology of pernicious anemia to the manifestations listed above. (See Pernicious Anemia.)