Chapter 6, Problem 22R

Elsa’s pediatrician suspects that she has thalassemia. Which of the following statements is true of thalassemia?   Thrombocytes tend to “stick together” and form blood clots.   Thalassemia is always caused by diet and environmental factors, not genetic makeup.   Thalassemia is also known as erythroblastic anemia and involves a reduced amount of hemoglobin in the blood.   Thalassemia is a type of hemophilia and is often hereditary in females.

Explain the relationships among plasma, tissue fluid, and lymph, in terms of movement of water throughout the body. Describe the system of lymph vessels. Explain how lymph is kept moving in these vessels. Into which veins is lymph emptied? Describe the location of the spleen and explain its functions. If the spleen is removed, what organs will compensate for its functions? Explain the function of the thymus, and state when (age) this function is most important.

Part A Which of the following problems would NOT be associated with thrombocytopenia, a lack of platelets in the blood? Which of the following problems would NOT be associated with thrombocytopenia, a lack of platelets in the blood? inability to form adequate clots in the CNS excessive clot formation at an injury site bleeding in the digestive tract excessive bleeding and bruising in the skin   SubmitRequest Answer

These structures are distributed throughout the body and act as mechanical and biological filters for the fluid of the body:     Lymph Nodes     Metarterioles     Red blood cells     Capillaries

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia.   Discussion Questions Discuss how the gastric abnormalities contribute to vitamin B12 and iron deficiency and how vitamin B12 deficiency causes complications associated with pernicious anemia. (See Pernicious Anemia—Pathophysiology, Etiology.)

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discussion Questions Discuss other tests that could be performed to diagnose this type of anemia. (See Pernicious Anemia—Diagnostic Tests.)

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia. Discussion Questions Relate the pathophysiology of pernicious anemia to the manifestations listed above. (See Pernicious Anemia.)

Mr. Johnson, age 57, presented to his physician with marked fatigue, nausea with occasional diarrhea, and a sore, swollen tongue. Lately he also has been experiencing a tingling feeling in his toes and a feeling of clumsiness. Microscopic examination of a blood sample indicated a reduced number of erythrocytes, many of which are megaloblasts, and a reduced number of leukocytes, including many large, hypersegmented cells. Hemoglobin and serum levels of vitamin B12 were below normal. Additional tests confirm pernicious anemia.   Discussion Questions Discuss the treatment available and the limitations.