Human Heredity: Principles and Issues
Human Heredity: Principles and Issues
11th Edition
ISBN: 9781305683952
Author: Michael Cummings
Publisher: Cengage Learning US
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Chapter 5.5, Problem 1GR
Summary Introduction

To determine: The possibility of mutation in the pathway of folate synthesis to cause Spina bifida (SB) in the absence of folate-fortified foods.

Introduction: SB is a complex birth defect that involves neural tube (important for the brain and spinal cord development) defects in the individual. The affected individuals suffer from muscle imbalance, crippling deformities, and even paralysis in some cases. The defect is caused by the mutation in the gene VANGL1. A folate-rich diet reduces the severity of the defect and its incidence by 70%.

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Human Heredity: Principles and Issues

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