Biology (MindTap Course List)
10th Edition
ISBN: 9781285423586
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Textbook Question
Chapter 55, Problem 13TYU
PREDICT How might a food web change if all decomposers were eliminated from it?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 55 Solutions
Biology (MindTap Course List)
Ch. 55.1 - Summarize the concept of energy flow through a...Ch. 55.1 - Explain typical pyramids of numbers, biomass, and...Ch. 55.1 - Distinguish between gross primary productivity and...Ch. 55.1 - VISUALIZE Draw a diagram tracing energy flow...Ch. 55.1 - What are trophic levels, and how are they related...Ch. 55.1 - How do gross primary productivity (GPP) and net...Ch. 55.2 - Describe the main steps in each of these...Ch. 55.2 - What are the roles of the following processes in...Ch. 55.2 - VISUALIZE Draw a diagram showing the five steps in...Ch. 55.2 - How does the phosphorus cycle proceed without a...
Ch. 55.3 - Summarize the effects of solar energy on Earths...Ch. 55.3 - Discuss the roles of solar energy and the Coriolis...Ch. 55.3 - Give two causes of regional precipitation...Ch. 55.3 - Discuss the effects of fire on certain ecosystems.Ch. 55.3 - What basic forces determine the circulation of the...Ch. 55.3 - What basic forces produce the main ocean currents?Ch. 55.3 - Prob. 3CCh. 55.4 - Briefly describe some of the long-term ecological...Ch. 55.4 - Prob. 1CCh. 55 - The movement of matter is _______________ in...Ch. 55 - A complex of interconnected food chains in an...Ch. 55 - The quantitative estimate of the total amount of...Ch. 55 - Which of the following equations shows the...Ch. 55 - Which of the following processes increase(s) the...Ch. 55 - In the nitrogen cycle, gaseous nitrogen is...Ch. 55 - Test Your Understanding 7. The conversion of...Ch. 55 - Which biogeochemical cycle does not have a gaseous...Ch. 55 - Test Your Understanding 9. Which of the following...Ch. 55 - Test Your Understanding 10 The periodic warming of...Ch. 55 - Test Your Understanding 11 A mountain range may...Ch. 55 - VISUALIZE Draw the simplest stable ecosystem you...Ch. 55 - PREDICT How might a food web change if all...Ch. 55 - Why is the cycling of matter essential to the...Ch. 55 - What would happen to the nitrogen cycle if all...Ch. 55 - Test Your Understanding 16 Would the microclimate...Ch. 55 - Test Your Understanding 17 INTERPRET DATA Examine...Ch. 55 - INTERTRET DATA Scientists have compiled databases...Ch. 55 - SCIENCE, TECHNOLOGY, AND SOCIETY How do humans...
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