BIOLOGY 12E CONNECT ACCESS CARD
BIOLOGY 12E CONNECT ACCESS CARD
12th Edition
ISBN: 9781264938513
Author: Raven
Publisher: MCG
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Chapter 52, Problem 1DA

Data analysis Two different genes have mutant alleles that cause this spotting phenotype. One gene encodes a signaling molecule. What Is the likely function of the other gene product?

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Summary Introduction

To determine: The function of other gene product in spotting phenotype, if one gene encodes a signaling molecule.

Introduction: A mutation can be defined as a sudden change that occurs in the DNA sequence, during DNA replication. It can also be caused by exposure to specific chemicals or radiation. Mutation contributes to genetic variability.

Explanation of Solution

Neural crest cell under the surface of ectoderm differentiates into pigment cells of the skin. Survival and migration of these cellsare affected by a mutation in genes leads to white spotting in the skin. Two different genes have a mutant allele that causes the spotting phenotype in humans and mice. One gene act as a signaling molecule then the other is likely to be a receptor for the molecule.

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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid is located on the outside of the soluble protein but not near an active site. O-H¨ A. What type of mutation occurred? O-H B. What 2 types of chemical bonds are found in the R-groups of each amino acid? The R groups are shaded. CH2 CH2 CH2 H2N-C-COOH H2N-C-COOH 1 H Glutamic acid H Aspartic acid C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules? D. Consider the chemical properties of the two amino acids and the location of the amino acid in the protein. Explain what effect this mutation will have on this protein's function and why.
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BIOLOGY 12E CONNECT ACCESS CARD

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