IA MODIFIED MASTERING BIOLOGY WITH E TEX
12th Edition
ISBN: 9780136781752
Author: Urry
Publisher: PEARSON
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Chapter 51, Problem 10TYU
SCIENCE, TECHNOLOGY, AND SOCIETY Researchers are very interested in studying Identical twins separated at birth and raised apart. So far, the data reveal that such twins frequently have similar personalities, mannerisms, habits, and interests. What general question do you think researchers hope to answer by studying such twins? Why do identical twins make good subjects for this research? What are the potential pitfalls of this research? What abuses might occur if the studies are not evaluated critically? Explain your thinking.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 51 Solutions
IA MODIFIED MASTERING BIOLOGY WITH E TEX
Ch. 51.1 - WHAT IF? Suppose you exposed various fish species...Ch. 51.1 - MAKE CONNECTIONS How is the lunar-linked rhythm...Ch. 51.1 - How might associative learning explain why...Ch. 51.2 - Prob. 1CCCh. 51.2 - Prob. 2CCCh. 51.2 - Why does the mode of fertilization correlate with...Ch. 51.3 - MAKE CONNECTIONS Balancing selection can maintain...Ch. 51.3 - WHAT IF? Suppose an infection in a common...Ch. 51.3 - Prob. 3CCCh. 51.4 - Prob. 1CC
Ch. 51.4 - Prob. 2CCCh. 51.4 - How is migration based on circannual rhythms...Ch. 51 - Prob. 51.1CRCh. 51 - In some spider species, the female eats the male...Ch. 51 - Prob. 51.3CRCh. 51 - Prob. 51.4CRCh. 51 - Prob. 1TYUCh. 51 - Prob. 2TYUCh. 51 - Female spotted sandpipers aggressively court males...Ch. 51 - Prob. 4TYUCh. 51 - Although many chimpanzees live in environments...Ch. 51 - Prob. 6TYUCh. 51 - Level 3: Synthesis/Evaluation 7. DRAW IT You are...Ch. 51 - EVOLUTION CONNECTION We often explain our behavior...Ch. 51 - SCIENTIFIC INQUIRY Scientists studying scrub jays...Ch. 51 - SCIENCE, TECHNOLOGY, AND SOCIETY Researchers are...Ch. 51 - WRITE ABOUT A THEME: INFORMATION Learning is...Ch. 51 - SYNTHESIZE YOUR KNOWLEDGE Acorn woodpeckers...
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