Chapter 5, Problem 5.16P

a)

Interpretation Introduction

Interpretation:

The precision and accuracy of the method when blood was fortified with EDTA to known levels has to be calculated.

Concept introduction:

Precision:-

Precision is validated by the repeatability of analyses of replicate samples and replicate portions of the same sample.

Accuracy:-

Accuracy is validated by analyzing certified reference materials, by relating results from different analytical methods,

They are,

Fortification (spike) recovery,

Standard additions,

Calibration checks,

Blanks and quality control samples (blind samples)

Method detection limit:-

In analytical chemistry, Method detection limit can be found by analyzing every single sample.

$\text{minimum detectable limit = }\frac{\text{3s}}{\text{m}}$

Lower limit of quantitation:-

In analytical chemistry, the smallest amount of sample which can be measured with reasonable accuracy.

$\text{lower limit of quantitation = }\frac{\text{10s}}{\text{m}}$

b)

Interpretation Introduction

Interpretation:

The signal and the concentration detection and quantitation limits for EDTA has to be calculated.

Concept introduction:

Precision:-

Precision is validated by the repeatability of analyses of replicate samples and replicate portions of the same sample.

Accuracy:-

Accuracy is validated by analyzing certified reference materials, by relating results from different analytical methods,

They are,

Fortification (spike) recovery,

Standard additions,

Calibration checks,

Blanks and quality control samples (blind samples)

Method detection limit:-

In analytical chemistry, Method detection limit can be found by analyzing every single sample.

$\text{minimum detectable limit = }\frac{\text{3s}}{\text{m}}$

Lower limit of quantitation:-

In analytical chemistry, the smallest amount of sample which can be measured with reasonable accuracy.

$\text{lower limit of quantitation = }\frac{\text{10s}}{\text{m}}$