FUNDAMENTALS OF BIOCHEMISTRY - LL FD
FUNDAMENTALS OF BIOCHEMISTRY - LL FD
5th Edition
ISBN: 9781119598022
Author: Voet
Publisher: WILEY
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Chapter 5, Problem 1E
Summary Introduction

To calculate: The number of ten different residue peptides constructed from eight amino acids.

Concept introduction: Protein is made up of one or more amino acids linked together to form a chain. The building blocks of the protein is called amino acids. In early hypothesis, the life forms used only eight different amino acids to build small peptides. The eight essential amino acids are isoleucine, leucine, methionine, lysine, histidine, phenylalanine, tryptophan, threonine, and valine. Amino acids are termed as residues if they release a hydrogen ion from the amine end or a hydroxyl ion from the carboxyl end, or both, water molecule is released as a result of formation of each amide bond.

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The sequence of amino acids forms primary structure that are linked together by peptide bonds. A large number of different protein molecules can be constructed using eight different amino acids with ten different residues. For a protein of n residues, there are 8n possible sequences. The single polypeptide chain of small protein molecule consists of 10 residues. Therefore, 810=1,073,741,824 . This is about one billion possibilities. Hence, for different 10-residue peptides, about one billion possibilities can be constructed from the eight amino acids.

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