Campbell Biology
Campbell Biology
12th Edition
ISBN: 9780135188743
Author: Urry
Publisher: PEARSON
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Chapter 49.5, Problem 2CC
Summary Introduction

To explain: How the dopamine activity is related to Schizophrenia, drug addiction and Parkinson’s disease.

Concept introduction:

Dopamine is a neurotransmitter released by neurons in brain which send signals to other neurons. After its release into synapse, it binds with the cell surface receptors of other neurons and, activates them to exert their action. In the nervous system, it is essential for motor functions, executing functions, reward, and so forth.

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The following table is from Kumar et. al. Highly Selective Dopamine D3 Receptor (DR) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J. Med Chem 2016.
The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. You are a chef in a fancy new science-themed restaurant. You have a recipe that calls for 1 teaspoon of resinferatoxin, but you feel uncomfortable serving foods with "toxins" in them. How much capsaicin could you substitute instead?
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