Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 4.6, Problem 14AYP
Differentiate between Bergey’s Manual of Systematic Bacteriology and Bergey’s Manual of Determinative Bacteriology.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 4 Solutions
Microbiology: A Systems Approach
Ch. 4.1 - List the structures all bacteria possess.Ch. 4.1 - Identify at least four structures that some, but...Ch. 4.1 - Prob. 3AYPCh. 4.1 - Prob. 4AYPCh. 4.1 - Provide at least four terms to describe bacterial...Ch. 4.2 - Describe the structure and function of five...Ch. 4.2 - Prob. 7AYPCh. 4.3 - Prob. 8AYPCh. 4.3 - Prob. 9AYPCh. 4.3 - Prob. 10AYP
Ch. 4.4 - Prob. 11AYPCh. 4.4 - Prob. 12AYPCh. 4.5 - List some differences between archaea and...Ch. 4.6 - Differentiate between Bergeys Manual of Systematic...Ch. 4.6 - Prob. 15AYPCh. 4.6 - Define a species in terms of bacteria.Ch. 4 - Which of the following is not found in all...Ch. 4 - Pili are tubular shafts in ____ bacteria that...Ch. 4 - Prob. 3MCQCh. 4 - Which of the following is a primary bacterial cell...Ch. 4 - Which of the following is present in both...Ch. 4 - Darkly stained granules are concentrated crystals...Ch. 4 - Bacterial endospores usually function in a....Ch. 4 - A bacterial arrangement in packets of eight cells...Ch. 4 - Prob. 9MCQCh. 4 - Prob. 10MCQCh. 4 - Prob. 11TFCh. 4 - A research microbiologist looking at evolutionary...Ch. 4 - Nanobes may or may not actually be bacteria.Ch. 4 - Both bacteria and archaea used to be known as...Ch. 4 - Prob. 15TFCh. 4 - Define the term ubiquitous and explain whether...Ch. 4 - Quorum sensing is a process used by many bacteria...Ch. 4 - Based upon your knowledge of cell wall structure,...Ch. 4 - Provide evidence in support of or refuting the...Ch. 4 - a.Describe the characteristics of an...Ch. 4 - Prob. 1VCCh. 4 - From chapter 1, figure 1.14. Study this figure....Ch. 4 - Prob. 1CM
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