Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780134433776
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman
Publisher: PEARSON
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Chapter 43.2, Problem 3CC
WHAT IF? In 2005, at least ten grizzly bears in the greater Yellowstone ecosystem were killed through contact with people. Most of these deaths resulted from three things: collisions with automobiles, hunters (of other animals) shooting when charged by a female grizzly bear with cubs nearby, and conservation managers killing bears that attacked livestock repeatedly. If you were a conservation manager, what steps might you take to minimize such encounters in Yellowstone?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 43 Solutions
Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
Ch. 43.1 - Prob. 1CCCh. 43.1 - Prob. 2CCCh. 43.1 - WHAT IF? Imagine two populations of a fish...Ch. 43.2 - How does the reduced genetic diversity of small...Ch. 43.2 - Prob. 2CCCh. 43.2 - WHAT IF? In 2005, at least ten grizzly bears in...Ch. 43.3 - Prob. 1CCCh. 43.3 - Prob. 2CCCh. 43.3 - Prob. 3CCCh. 43.4 - How can the addition of excess mineral nutrients...
Ch. 43.4 - MAKE CONNECTIONS There are vast stores of organic...Ch. 43.5 - Prob. 1CCCh. 43.5 - Prob. 2CCCh. 43.6 - Prob. 1CCCh. 43.6 - Prob. 2CCCh. 43.6 - WHAT IF? Suppose a new fishery is discovered, and...Ch. 43 - One characteristic that distinguishes a population...Ch. 43 - Prob. 2TYUCh. 43 - Prob. 3TYUCh. 43 - Prob. 4TYUCh. 43 - Prob. 5TYUCh. 43 - Prob. 6TYUCh. 43 - DRAW IT (a) Estimate the average CO2 concentration...Ch. 43 - Prob. 8TYUCh. 43 - FOCUS ON EVOLUTION The fossil record indicates...Ch. 43 - Prob. 10TYUCh. 43 - SYNTHESIZE YOUR KNOWLEDGE Big cats, such as the...
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