Biology with Connect Access Card
10th Edition
ISBN: 9780077705701
Author: Raven, Peter
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 4, Problem 5A
The protein sorting pathway involves the following organelles/compartments in order:
a. SER, RER, transport vesicle, Golgi.
b. RER, lysosome, Golgi.
c. RER, transport vesicle, Golgi, final destination.
d. Golgi, transport vesicle, RER, final destination.
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 4 Solutions
Biology with Connect Access Card
Ch. 4 - Which of the following statements is NOT part of...Ch. 4 - All cells have all of the following except a....Ch. 4 - Eukaryotic cells are more complex than prokaryotic...Ch. 4 - Which of the following are differences between...Ch. 4 - The cytoskeleton includes a. microtubules made of...Ch. 4 - The smooth endoplasmic reticulum is a. involved in...Ch. 4 - Plasmodesmata in plants and gap junctions in...Ch. 4 - The most important factor that limits the size of...Ch. 4 - All eukaryotic cells possess each of the following...Ch. 4 - Adherens junctions, which contain cadherin, are...
Ch. 4 - Different motor proteins like kinesin and myosin...Ch. 4 - The protein sorting pathway involves the following...Ch. 4 - Chloroplasts and mitochondria have many common...Ch. 4 - Prob. 7ACh. 4 - The smooth endoplasmic reticulum is the site of...Ch. 4 - Use the information provided in table 4.3 to...Ch. 4 - Prob. 3SCh. 4 - The protist Giardia intestinalis is the organism...
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