EBK MICROBIOLOGY
12th Edition
ISBN: 8220100659720
Author: CASE
Publisher: PEARSON
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Chapter 4, Problem 3CAE
Live cultures of Bacillus thuringiensis (Dipel) and B. subtilis (Kodiak) are sold as pesticides. What bacterial structures make it possible to package and sell these bacteria? For what purpose is each product used? (Hint: Refer to Chapter 11.)
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 4 Solutions
EBK MICROBIOLOGY
Ch. 4 - DRAW IT Diagram each of the following flagellar...Ch. 4 - Endospore formation is called (a) _____. It is...Ch. 4 - DRAW IT Draw the bacterial shapes listed in (a),...Ch. 4 - Match the structures in column A to their...Ch. 4 - Why is an endospore called a resting structure? Of...Ch. 4 - Compare and contrast the following a. simple...Ch. 4 - Prob. 7RCh. 4 - Starch is readily metabolized by many cells, but a...Ch. 4 - Match the characteristics of eukaryotic cells in...Ch. 4 - NAME IT What group of microbes is characterized by...
Ch. 4 - Which of the following is not a distinguishing...Ch. 4 - Which statement best describes what happens when a...Ch. 4 - Which statement best describes what happens when a...Ch. 4 - Which statement best describes what happens when a...Ch. 4 - Which of the following statements best describes...Ch. 4 - Which of the following is false about fimbriae? a....Ch. 4 - Which of the following pairs is mismatched? a....Ch. 4 - Which of the following pairs is mismatched? a....Ch. 4 - You have isolated a motile, gram-positive cell...Ch. 4 - The antibiotic amphothericin B disrupts plasma...Ch. 4 - How can prokaryotic cells be smaller than...Ch. 4 - The smallest eukaryotic cell is the motile alga...Ch. 4 - Two types of prokaryotic cells have been...Ch. 4 - In 1985, a 0.5-mm cell was discovered in...Ch. 4 - When E. coli cells are exposed to a hypertonic...Ch. 4 - Clostridium botulinum is a strict anaerobe; that...Ch. 4 - A South San Francisco child enjoyed bath time at...Ch. 4 - Live cultures of Bacillus thuringiensis (Dipel)...
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