The Immune System, 4th Edition
The Immune System, 4th Edition
4th Edition
ISBN: 9780815344667
Author: Peter Parham
Publisher: W. W. Norton & Company
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Chapter 4, Problem 1Q
Summary Introduction

Introduction:

The immunoglobulins or the antibodies are the glycoprotein molecules formed by the plasma cells. The immunoglobulins play a major role in the immune response and the immunity.

Expert Solution & Answer
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Answer to Problem 1Q

Correct answer:

The correct answer is option (c) paired V regions of a single heavy chain and a single light chain.

Explanation of Solution

Explanation/justification for the correct answer:

Option (c) paired V regions of a single heavy chain and a single light chain. The antigen binding site of the immunoglobulin is the site where the antigen's surface is attached to the immunoglobin. The Fab fragment is the site of the antigen binding, which is composed of a constant region and one variable (V) region of a single heave and a single light chain. Hence, it is a correct answer.

Explanation for the incorrect answer:

Option (a) the V regions of light chains only. The Fab region consist of both heavy and the light chain. Hence, this is an incorrect answer.

Option (b) the C regions of heavy chains only. The Fab region consist of both constant and variable region of a single and a light chain. So, this is an incorrect answer.

Option (d) paired V regions of two light chains. The Fab region consist of both constant and variable region of a single and a light chain. Hence, it is an incorrect option.

Option (e) paired C regions of two heavy chains. The Fab region consist of both constant and variable region of a single and a light chain. Hence, it is an incorrect answer.

Conclusion

The Fab fragment is the site of the antigen binding, which is composed of a constant region and one variable (V) region of a single heave and a single light chain. Hence, the correct answer is option (c).

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