The control of cell processes, directly or indirectly by DNA. Concept introduction: Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

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Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

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Kinetics: One-Compartment First-Order Absorption 1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration. Using this data and set of graphs, determine:(calculate for each variable) (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e)absolute ip bioavailability, Fip (f) absolute po bioavailability, Fpo

3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug: (a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate) (b) Estimate the time for maximum plasma concentration (tmax). (c) Estimate the maximum plasma concentration (Cmax). (d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.) (e)…

Answer 2

Question

Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

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Answer 3

Question

Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Expert Solution & Answer

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Answer 4

Question

Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Expert Solution & Answer

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Answer 5

Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Answer 6

Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Answer 7

Chapter 4, Problem 19DYKB

Summary Introduction

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Answer 8

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Answer 11

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The control of cell processes, directly or indirectly by DNA. Concept introduction: Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Solution Summary: The author explains that DNA is a double helical structure present in the nucleus of eukaryotic cell.

Concept explainers

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To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Want to see the full answer?

Chapter 4 Solutions

The control of cell processes, directly or indirectly by DNA. Concept introduction: Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Solution Summary: The author explains that DNA is a double helical structure present in the nucleus of eukaryotic cell.

Concept explainers

Videos

To explain: The control of cell processes, directly or indirectly by DNA. Concept introduction: Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.

Want to see the full answer?

Chapter 4 Solutions

To explain: The control of cell processes, directly or indirectly by DNA.

Concept introduction:

Chromosomes are composed of DNA and protein; they are thread-like gene carrying structure. Genes are sequences of nucleotides present in DNA and are decoded in RNA and proteins.