ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 4, Problem 14DYKB
Describe the active processes of membrane transport including primary active transport, secondary active transport, and the various forms of vesicular transport.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 4 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 4.1 - What is the advantage of using a TEM instead of an...Ch. 4.1 - Prob. 2WDYLCh. 4.1 - What are the three main structural features of a...Ch. 4.1 - What cellular structure is responsible for forming...Ch. 4.2 - How do lipids maintain the basic physical barrier...Ch. 4.2 - What type of plasma membrane protein provides the...Ch. 4.3 - How does O2 diffuse into a cell and CO2 diffuse...Ch. 4.3 - Prob. 8WDYLCh. 4.3 - Define osmosis.Ch. 4.3 - What occurs to the tonicity of a cell when it is...
Ch. 4.3 - What general conclusion can you make concerning...Ch. 4.3 - What transport process involved in the movement of...Ch. 4.3 - Diagram a flowchart for the active processes of...Ch. 4.4 - Define a resting membrane potential.Ch. 4.4 - Prob. 15WDYLCh. 4.5 - What are some examples of how cells communicate...Ch. 4.5 - How do action of enzymatic receptors and G...Ch. 4.6 - Describe the general structure of both the...Ch. 4.6 - Lysosomes and peroxisomes are both small...Ch. 4.6 - Which non-membrane-bound organelle functions (a)...Ch. 4.6 - Which cellular surface structure functions in (a)...Ch. 4.6 - Which cellular junction (a) provides resistance to...Ch. 4.7 - What is the function of nuclear pores within the...Ch. 4.7 - What is the function of the nucleolus?Ch. 4.7 - Describe the structural relationship of DNA and...Ch. 4.8 - What are the three major structures required for...Ch. 4.8 - What is a codon and an anticodon?Ch. 4.8 - How is mRNA attached to ribosomes and translated...Ch. 4.8 - The genetic code of DNA is the specific...Ch. 4.9 - How is chromatin distinguished from a chromosome?Ch. 4.9 - Describe the process of DNA replication that...Ch. 4.9 - What are the events that occur during the mitotic...Ch. 4.10 - What are the specific changes that occur to DNA...Ch. 4 - Prob. 1DYKBCh. 4 - _____ 2. The molecule that is responsible for most...Ch. 4 - Prob. 3DYKBCh. 4 - Prob. 4DYKBCh. 4 - Prob. 5DYKBCh. 4 - Prob. 6DYKBCh. 4 - Prob. 7DYKBCh. 4 - Prob. 8DYKBCh. 4 - _____ 9. During this stage of mitosis, the...Ch. 4 - _____ 10. Erythrocytes do not have a nucleus. In...Ch. 4 - Prob. 11DYKBCh. 4 - Prob. 12DYKBCh. 4 - Describe the passive processes of membrane...Ch. 4 - Describe the active processes of membrane...Ch. 4 - List the membrane-bound structures, and describe...Ch. 4 - Prob. 16DYKBCh. 4 - Prob. 17DYKBCh. 4 - Prob. 18DYKBCh. 4 - Prob. 19DYKBCh. 4 - Explain the processes that occur in the different...Ch. 4 - Michael was born with Tay-Sachs disease. Which of...Ch. 4 - Prob. 2CALCh. 4 - Prob. 3CALCh. 4 - Prob. 4CALCh. 4 - Prob. 5CALCh. 4 - Prob. 1CSLCh. 4 - Prob. 2CSLCh. 4 - Prob. 3CSL
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