CAMPBELL BIOLOGY IN FOCUS (LL)-W/MOD.MA
3rd Edition
ISBN: 9780135686065
Author: Urry
Publisher: PEARSON
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Chapter 35, Problem 7TYU
DRAW IT Consider a pencil-shaped protein with two epitopes, Y (the “eraser” end) and Z (the “point”· end). They are recognized by antibodies A1 and A2, respectively. Draw and label a picture showing the antibodies linking proteins into a complex that could trigger endocytosis by a macrophage.
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Consider a pencil-shaped protein with two epitopes, Y (the “eraser” end) and Z (the “point” end). They are recognized by antibodies A1 and A2, respectively. Draw and label a picture showing the antibodies linking proteins into a complex that could trigger endocytosis by a macrophage.
How are antibodies unique? Please discuss the structure of an antibody. What are the V and C regions? Discuss how the few hundred genes involved are capable of making endless amounts of antibodies. Besides medical treatment what is another way antibodies can be used?
For the diagram below, all of the following
statements are true EXCEPT:
Antigen-
binding
site
V C
Heavy chain
V
Light chain
S.S.
Fc (stem) region c C Hinge region
None of the other four answers (All are
true statements)
Antibodies (Immunoglobulins) are composed
of four protein molecules, two identical "light"
chains and two identical "heavy" chains
Antigens bind to the "stem", composed of
the constant regions of the two "heavy"
chains
The variable (V) regions form the antigen
binding sites
The constant (C) regions determine class of
antibody
Chapter 35 Solutions
CAMPBELL BIOLOGY IN FOCUS (LL)-W/MOD.MA
Ch. 35.1 - Pus is both a sign of infection and an indicator...Ch. 35.1 - MAKE CONNECTIONS How do the molecules that...Ch. 35.1 - Prob. 3CCCh. 35.2 - Prob. 1CCCh. 35.2 - Explain how memory cells strengthen the immune...Ch. 35.2 - WHAT IF? If both copies of a light-chain gene and...Ch. 35.3 - Prob. 1CCCh. 35.3 - Prob. 2CCCh. 35.3 - Prob. 3CCCh. 35 - Prob. 1TYU
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- Observe the structure of antibodies below that has four protein subunits. Explain why we only see two (not four) bands on the SDS PAGE gel.arrow_forwardWrite T if the statement is correct; write F if the statement is not correct. P and E selectins are expressed by endothelial cells. " " TCRs consist of heavy and light chains. " " A disulfide bond can be found on TCRs. " " The antigen binding site in TCRs is contributed by the variable region of the H chain and the variable region of the light chain. " " CD4, but not CD8, interacts with Lck. " "arrow_forwardDraw the structure of an antibody molecule(a typical IgG)and show how this structure enables it to bind to a specific antigen. Include the following terms in your diagranm: heavy chain (H chain), light chain (L chain), variable region, constant region, Fab, Fc, hinge and disulfide bonds.arrow_forward
- Each of the following statements concerning the macrophages is true, EXCEPT:* D Sometimes referred to Langerhans cells in the skin Contain numerous primary and secondary lysosomes Have variable shape, because they move in connective tissues O D Manufacture antibodies. O O Phagocytosis of bacteriaarrow_forwardWhich antibody type description among A- D is falsely characterized? A) O IgA: form dimers; prevent adherence of pathogens to mucosal surfaces 1f1 B) O IgG: circulating antibody with multiple functions; formed in high numbers in secondary antibody response C) O IgM: forms multimers whose function is agglutination of infectious microbes D) O IgE, IgD: carry out their function while bound to the surfaces of specific cell types E) O None are false, A-D are all correctarrow_forwardIllustrate the structure of an antibody molecule. Label the constant and variable regions, the Fc and Fab parts, and the heavy and light chains.arrow_forward
- Addition of immunoglobulin G (IgG) specific for hemoglobin to a solution of hemoglobin results in the formation of a red precipitate. In contrast, addition of the Fab fragments from this antibody to hemoglobin results in no such precipitate. What could explain this difference in results? Treatment with papain produces Fab fragments with different antigen specificity than the original IgG molecule. IgG can simultaneously bind two different antigens, whereas an Fab fragment can only bind one antigen at a time. The Fab fragments preferentially bind to other Fab fragments rather than to hemoglobin. The hemoglobin molecule antibody-binding sites can bind IgG molecules, but cannot bind Fab fragments.arrow_forwardThe figure above depicts an antibody. For the labeled areas, which statement among A-D is not correct? A) O Mature, functional IgA antibodies possess a total of two sites labeled A B) O Your IgM antibodies are all similar in these areas: A C) O During opsonization, area B would bind to a bacterium D) O Your IgD antibodies are all different in this area: B 111 E) O None are matched correctly. B.arrow_forwardSerum from individuals with high levels of antibody to SARS-CoV2 has been used to treat patients with severe COVID-19. What is ONE way (there are several) that passive immunization with the antibody to the virus could help these patients? HINT: think about what opsonization with antibody could do for the innate immune response.arrow_forward
- The indirect immunofluorescence ("fluorescent Ab") test shown below is performed to test for: + AA T. pallidum from Specific antibodies laboratory stock in serum of patient Antibodies bind to T. pallidum + ㅅ Fluorescent dye-labeled anti-human immune serum globulin (This will react with any immunoglobulin) Da Fluorescent spirochetes (see Figure 3.6b) None of the other four answers are correct The presence of T. pallidum bacteria in the patient's blood Whether the patient has made antibodies against other human antibodies Immunologic evidence of current or past infection with T. pallidum (i.e., Ab against T. pallidum) Growth of T. pallidum in culture from a syphilis patientarrow_forwardSketch a B cell antigen receptor. Label the V and C regions of the light and heavy chains. Label the antigenbinding sites, disulfide bridges, and transmembrane region. Where are these features located relative to the V and C regions?arrow_forwardConstruct a typical antibody (immunoglobulin) molecule. Label the variable and constant regions, and the light and heavy chains. Indicate which region determines the antibody’s isotype (class). Indicate which region determines its antigenic specificity.arrow_forward
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