CAMPBELL BIOLOGY IN FOCUS-MOD.MASTERING
3rd Edition
ISBN: 9780135191811
Author: Urry
Publisher: PEARSON
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Chapter 34.5, Problem 1CC
Why is an internal location for gas exchange tissues advantageous for terrestrial animals?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 34 Solutions
CAMPBELL BIOLOGY IN FOCUS-MOD.MASTERING
Ch. 34.1 - How is the now of hemolymph through an open...Ch. 34.1 - Three-chambered hearts with incomplete septa were...Ch. 34.1 - Prob. 3CCCh. 34.2 - Prob. 1CCCh. 34.2 - Why is it important that the AV node delay the...Ch. 34.2 - Prob. 3CCCh. 34.3 - What is the primary cause of the low velocity of...Ch. 34.3 - Prob. 2CCCh. 34.3 - Prob. 3CCCh. 34.4 - Prob. 1CC
Ch. 34.4 - Prob. 2CCCh. 34.4 - Prob. 3CCCh. 34.4 - Prob. 4CCCh. 34.5 - Why is an internal location for gas exchange...Ch. 34.5 - After a heavy rain, earthworms come to the...Ch. 34.5 - MAKE CONNECTIONS Describe similarities in the...Ch. 34.6 - Prob. 1CCCh. 34.6 - Prob. 2CCCh. 34.6 - WHAT IF? If an injury tore a small hole in the...Ch. 34.7 - What determines whether O2, or CO2, undergoes net...Ch. 34.7 - How does the Bohr shift help deliver O2, to very...Ch. 34.7 - Prob. 3CCCh. 34 - Which of the following respiratory systems is not...Ch. 34 - Blood returning to the mammalian heart in a...Ch. 34 - Pulse is a direct measure of A. blood pressure. B....Ch. 34 - Prob. 4TYUCh. 34 - One feature that amphibians and humans have in...Ch. 34 - If a molecule of CO2 released into the blood in...Ch. 34 - Prob. 7TYUCh. 34 - DRAW IT Plot blood pressure against time for one...Ch. 34 - Prob. 9TYUCh. 34 - Prob. 10TYUCh. 34 - Prob. 11TYUCh. 34 - SYNTHESIZE YOUR KNOWLEDGE The diving bell spider...
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