HUMAN BIOLOGY (LOOSELEAF)
16th Edition
ISBN: 9781260482690
Author: Mader
Publisher: MCG
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Chapter 3.3, Problem 5LO
Summarize how eukaryotic cells move large molecules across membranes.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 3 Solutions
HUMAN BIOLOGY (LOOSELEAF)
Ch. 3.1 - State the basic principles of the cell theory.Ch. 3.1 - Prob. 2LOCh. 3.1 - Prob. 3LOCh. 3.1 - Discuss how a researcher might use a GFP-labeled...Ch. 3.1 - How might a meal of a cheeseburger and fries be...Ch. 3.1 - Summarize the cell theory and state its importance...Ch. 3.1 - Prob. 2CYPCh. 3.1 - Prob. 3CYPCh. 3.2 - Distinguish between the structure of a prokaryotic...Ch. 3.2 - Identify the role of the plasma membrane and...
Ch. 3.2 - Summarize how eukaryotic cells evolved from...Ch. 3.2 - Summarize the role of the plasma membrane in a...Ch. 3.2 - Describe the main differences between a eukaryotic...Ch. 3.2 - Describe the possible evolution of the nucleus,...Ch. 3.3 - Prob. 1LOCh. 3.3 - Prob. 2LOCh. 3.3 - Explain how tonicity relates to the direction of...Ch. 3.3 - Compare passive-transport and active-transport...Ch. 3.3 - Summarize how eukaryotic cells move large...Ch. 3.3 - Summarize how the fluid-mosaic model describes the...Ch. 3.3 - Prob. 2CYPCh. 3.3 - Prob. 3CYPCh. 3.4 - Describe the structure of the nucleus and explain...Ch. 3.4 - Summarize the function of the organelles of the...Ch. 3.4 - 3. Explain the role and location of the...Ch. 3.4 - Prob. 1CYPCh. 3.4 - Explain how the nucleus, ribosomes, and rough...Ch. 3.4 - Prob. 3CYPCh. 3.5 - Prob. 1LOCh. 3.5 - Summarize the major protein fibers In the...Ch. 3.5 - Prob. 3LOCh. 3.5 - Prob. 4LOCh. 3.5 - Prob. 1CYPCh. 3.5 - Prob. 2CYPCh. 3.5 - Prob. 3CYPCh. 3.6 - Prob. 1LOCh. 3.6 - Prob. 2LOCh. 3.6 - Summarize the roles of the anaerobic and aerobic...Ch. 3.6 - Prob. 4LOCh. 3.6 - How might a meal of a cheeseburger and fries be...Ch. 3.6 - Even though Figure 3B does not indicate the need...Ch. 3.6 - Summarize the roles of enzymes in chemical...Ch. 3.6 - Prob. 2CYPCh. 3.6 - Explain why the ATP cycle resembles that of a...Ch. 3.6 - Prob. 4CYPCh. 3 - Prob. 1ACh. 3 - The cell theory states that all life comes from...Ch. 3 - Prob. 3ACh. 3 - 4.The endosymbiotic theory explains which of the...Ch. 3 - Which of the following is not part of the...Ch. 3 - Prob. 6ACh. 3 - Prob. 7ACh. 3 - Prob. 8ACh. 3 - Prob. 9ACh. 3 - Prob. 10ACh. 3 - Prob. 11ACh. 3 - Prob. 12ACh. 3 - The cytoskeleton of a cell consists of all of the...Ch. 3 - Prob. 14ACh. 3 - Prob. 15ACh. 3 - Prob. 16ACh. 3 - Prob. 17ACh. 3 - Prob. 18ACh. 3 - Prob. 1TCCh. 3 - Prob. 2TCCh. 3 - Prob. 3TC
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