PRESCOTT'S MICROBIOLOGY
11th Edition
ISBN: 2818440045677
Author: WILLEY
Publisher: MCG
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Chapter 32.3, Problem 4CC
Summary Introduction
To determine: The detailed account of the three outcomes of complement activation.
Introduction: The complement system is the ancient type if innate immunity that if found in a primitive invertebrate, including mammals. It is called such because at the time, it was discovered the collection of nearly 30 heat-labile serum proteins obtained to be “complement” the antimicrobial effects of additional components of the immune system.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 32 Solutions
PRESCOTT'S MICROBIOLOGY
Ch. 32.1 - Prob. 1CCCh. 32.1 - Prob. 2CCCh. 32.2 - Why is the skin such a good first line of defense...Ch. 32.2 - Prob. 2CCCh. 32.3 - What strategies could a Gram-negative bacterium...Ch. 32.3 - Prob. 1CCCh. 32.3 - Prob. 2CCCh. 32.3 - Prob. 3CCCh. 32.3 - Prob. 4CCCh. 32.3 - Prob. 5CC
Ch. 32.3 - Prob. 6CCCh. 32.3 - Prob. 7CCCh. 32.4 - Prob. 1MICh. 32.4 - Describe the structure and function of each of the...Ch. 32.4 - Prob. 2CCCh. 32.4 - Prob. 3CCCh. 32.4 - Prob. 4CCCh. 32.4 - Prob. 5CCCh. 32.4 - Discuss the role of NK cells in protecting the...Ch. 32.5 - Prob. 1MICh. 32.5 - Prob. 1CCCh. 32.5 - Injury to the spleen can lead to its removal. What...Ch. 32.5 - Describe SALT and MALT functions in innate...Ch. 32.6 - Prob. 1CCCh. 32.6 - Prob. 2CCCh. 32.6 - Prob. 3CCCh. 32.7 - Prob. 1MICh. 32.7 - Prob. 1CCCh. 32.7 - Prob. 2CCCh. 32 - Prob. 1RCCh. 32 - Prob. 2RCCh. 32 - Prob. 1ALCh. 32 - Prob. 2ALCh. 32 - Prob. 3ALCh. 32 - Prob. 4AL
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