Understanding Pathophysiology, 6e
Understanding Pathophysiology, 6e
6th Edition
ISBN: 9780323354097
Author: Sue E. Huether RN PhD, Kathryn L. McCance RN PhD
Publisher: Elsevier Science
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Chapter 3.1, Problem 1QC
Summary Introduction

To define: The term epigenetics.

Concept introduction: All the cells in an organism consist of similar DNA, but the cell types and their functions vary because of differential gene expression. It results due to the inheritance of genetic and non-genetic information.

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The inheritance which occurs without any alteration in the genetic sequences is known as epigenetics. The term ‘epigenetic’ means ‘in addition to change in nucleotide sequence’. It leads to the alteration of gene activity that can be transmitted to daughter cells. There are three major epigenetic modifications referred to as histone modifications, DNA methylation, and RNA-based mechanisms. These regulate gene expression at the transcription level.

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