ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
9th Edition
ISBN: 9781307677720
Author: SALADIN
Publisher: MCG/CREATE
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Chapter 3, Problem 4WWTS
Summary Introduction
Introduction:
Cellular membrane, nucleus, and cytoplasm are the three major components of a cell. Cellular membrane, which surrounds the entire cell, is composed of phospholipids and proteins. The nucleus is bound by a nuclear membrane, and it possesses the genetic material of the cell. Cytoplasm consists of organelles, cytoskeleton (filaments and tubules), and inclusion bodies. Other organelles present in a cell include endoplasmic reticulum, ribosomes, Golgi complex, mitochondria, centrioles, peroxisomes, and lysosomes. Protoplasm denotes all living material that are present in the cell enclosed by the cellular membrane (inside and outside the nucleus).
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
ANATOMY & PHYS VOL 2(CH 18-29) >CUSTOM<
Ch. 3.1 - What are the base principles of the cell theory?Ch. 3.1 - What does it mean to say a cell is squamous,...Ch. 3.1 - Why can cells not grow to unlimited size?Ch. 3.1 - What is the difference between cytoplasm and...Ch. 3.1 - Define intracellular fluid (ICF) and extracellular...Ch. 3.1 - Prob. 1AYLOCh. 3.1 - Basic tenets of the cell theoryCh. 3.1 - The nine common cell shapesCh. 3.1 - Prob. 4AYLOCh. 3.1 - Prob. 5AYLO
Ch. 3.1 - Basic structural components of a cellCh. 3.1 - Prob. 7AYLOCh. 3.2 - Prob. 6BYGOCh. 3.2 - Prob. 7BYGOCh. 3.2 - Prob. 8BYGOCh. 3.2 - Prob. 9BYGOCh. 3.2 - Prob. 10BYGOCh. 3.2 - Prob. 11BYGOCh. 3.2 - Prob. 12BYGOCh. 3.2 - The molecules of the plasma membrane and how they...Ch. 3.2 - Prob. 2AYLOCh. 3.2 - Prob. 3AYLOCh. 3.2 - Prob. 4AYLOCh. 3.2 - Prob. 5AYLOCh. 3.2 - Prob. 6AYLOCh. 3.2 - Prob. 7AYLOCh. 3.2 - Prob. 8AYLOCh. 3.2 - Prob. 9AYLOCh. 3.2 - Structure and function of pseudopodsCh. 3.3 - Prob. 13BYGOCh. 3.3 - Prob. 14BYGOCh. 3.3 - Prob. 15BYGOCh. 3.3 - Prob. 16BYGOCh. 3.3 - Prob. 17BYGOCh. 3.3 - Prob. 18BYGOCh. 3.3 - Prob. 19BYGOCh. 3.3 - Prob. 20BYGOCh. 3.3 - Prob. 21BYGOCh. 3.3 - Prob. 1AYLOCh. 3.3 - Prob. 2AYLOCh. 3.3 - Prob. 3AYLOCh. 3.3 - Prob. 4AYLOCh. 3.3 - Prob. 5AYLOCh. 3.3 - Prob. 6AYLOCh. 3.3 - Prob. 7AYLOCh. 3.3 - Prob. 8AYLOCh. 3.3 - Prob. 9AYLOCh. 3.3 - Prob. 10AYLOCh. 3.3 - Prob. 11AYLOCh. 3.3 - Prob. 12AYLOCh. 3.3 - Prob. 13AYLOCh. 3.3 - Prob. 14AYLOCh. 3.3 - Of the preceding mechanisms of transport, which...Ch. 3.4 - Prob. 22BYGOCh. 3.4 - Briefly state how each of the following cell...Ch. 3.4 - Prob. 24BYGOCh. 3.4 - Prob. 25BYGOCh. 3.4 - Prob. 26BYGOCh. 3.4 - Prob. 1AYLOCh. 3.4 - Prob. 2AYLOCh. 3.4 - Prob. 3AYLOCh. 3.4 - Prob. 4AYLOCh. 3.4 - General structure of the endoplasmic reticulum...Ch. 3.4 - Prob. 6AYLOCh. 3.4 - Prob. 7AYLOCh. 3.4 - Prob. 8AYLOCh. 3.4 - Prob. 9AYLOCh. 3.4 - Prob. 10AYLOCh. 3.4 - Structures and functions of centrioles, the...Ch. 3.4 - Prob. 12AYLOCh. 3 - The clear, structureless gel in a cell is its a....Ch. 3 - Prob. 2TYRCh. 3 - Which of the following processes could occur only...Ch. 3 - Prob. 4TYRCh. 3 - Prob. 5TYRCh. 3 - Membrane carriers resemble enzymes except for tie...Ch. 3 - The cotransport of glucose derives energy from a....Ch. 3 - Prob. 8TYRCh. 3 - Most cellular membranes are made by a. the...Ch. 3 - Prob. 10TYRCh. 3 - Prob. 11TYRCh. 3 - Prob. 12TYRCh. 3 - Prob. 13TYRCh. 3 - Prob. 14TYRCh. 3 - Prob. 15TYRCh. 3 - Prob. 16TYRCh. 3 - Prob. 17TYRCh. 3 - Prob. 18TYRCh. 3 - Prob. 19TYRCh. 3 - Prob. 20TYRCh. 3 - Prob. 1BYMVCh. 3 - chromato-Ch. 3 - Prob. 3BYMVCh. 3 - Prob. 4BYMVCh. 3 - Prob. 5BYMVCh. 3 - Prob. 6BYMVCh. 3 - Prob. 7BYMVCh. 3 - Prob. 8BYMVCh. 3 - Prob. 9BYMVCh. 3 - Prob. 10BYMVCh. 3 - Prob. 1WWTSCh. 3 - Prob. 2WWTSCh. 3 - Prob. 3WWTSCh. 3 - Prob. 4WWTSCh. 3 - Prob. 5WWTSCh. 3 - Prob. 6WWTSCh. 3 - Prob. 7WWTSCh. 3 - Prob. 8WWTSCh. 3 - Prob. 9WWTSCh. 3 - Prob. 10WWTSCh. 3 - If someone bought a saltwater fish in a pet shop...Ch. 3 - Prob. 2TYCCh. 3 - Prob. 3TYCCh. 3 - It is often said, even in some textbooks, that...Ch. 3 - Prob. 5TYC
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