Human Anatomy (9th Edition)
9th Edition
ISBN: 9780134320762
Author: Frederic H. Martini, Robert B. Tallitsch, Judi L. Nath
Publisher: PEARSON
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Chapter 3, Problem 3RFT
Match each numbered item with the most closely related lettered item.
avascular..............
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
Human Anatomy (9th Edition)
Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most | closely...Ch. 3 - Match each numbered item with the most closely...Ch. 3 - Match each numbered item with the most closely...
Ch. 3 - 11. Label the following photomicrographs with the...Ch. 3 - Which of the following refers to the dense...Ch. 3 - The reduction of friction between the parietal and...Ch. 3 - Which of the following is not a characteristic of...Ch. 3 - Functions of connective tissue include all of the...Ch. 3 - What type of supporting tissue is found in the...Ch. 3 - An epithelium is connected to underlying...Ch. 3 - Which of the following are wandering cells found...Ch. 3 - Compare and contrast the role of a tissue in the...Ch. 3 - Compare and contrast the functions of a tendon and...Ch. 3 - Prob. 3RCCh. 3 - Analyze the significance of the cilia on the...Ch. 3 - Prob. 5RCCh. 3 - A layer of glycoproteins and a network of fine...Ch. 3 - Prob. 7RCCh. 3 - Prob. 8RCCh. 3 - Identify what stem cells are and analyze their...Ch. 3 - Prob. 1CTCh. 3 - Prob. 2CTCh. 3 - 3. Assess why cardiac muscle ischemia (inadequate...
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