Principles of Anatomy and Physiology
16th Edition
ISBN: 9781119662792
Author: Tortora, Gerard J., DERRICKSON, Bryan H.
Publisher: WILEY
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Chapter 3, Problem 12CP
What is the key difference between passive and active processes?
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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the
encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid
is located on the outside of the soluble protein but not near an active site.
O-H¨
A. What type of mutation occurred?
O-H
B. What 2 types of chemical bonds are found in the R-groups
of each amino acid? The R groups are shaded.
CH2
CH2
CH2
H2N-C-COOH
H2N-C-COOH
1
H
Glutamic acid
H
Aspartic acid
C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules?
D. Consider the chemical properties of the two amino acids and the location of the amino acid in the
protein. Explain what effect this mutation will have on this protein's function and why.
engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?
Molecular Biology
Please help with question. thank you
You are studying the expression of the lac operon. You have isolated mutants as described below. In the presence of glucose, explain/describe what would happen, for each mutant, to the expression of the lac operon when you add lactose AND what would happen when the bacteria has used up all of the lactose (if the mutant is able to use lactose).5. Mutations in the lac operator that strengthen the binding of the lac repressor 200 fold
6. Mutations in the promoter that prevent binding of RNA polymerase
7. Mutations in CRP/CAP protein that prevent binding of cAMP8. Mutations in sigma factor that prevent binding of sigma to core RNA polymerase
Chapter 3 Solutions
Principles of Anatomy and Physiology
Ch. 3 - Prob. 1CPCh. 3 - Checkpoint 2:
How do hydrophobic and hydrophilic...Ch. 3 - What substances can and cannot diffuse through the...Ch. 3 - “The proteins present in a plasma membrane...Ch. 3 - Checkpoint 5:
How does cholesterol affect membrane...Ch. 3 - Checkpoint 6:
Why are membranes said to have...Ch. 3 - Checkpoint 7:
What factors contribute to an...Ch. 3 - Checkpoint 8:
What factors can increase the rate...Ch. 3 - Checkpoint 9:
How does simple diffusion compare...Ch. 3 - Prob. 10CP
Ch. 3 - Distinguish among isotonic, hypotonic, and...Ch. 3 - What is the key difference between passive and...Ch. 3 - Checkpoint 13:
How do symporters and antiporters...Ch. 3 - What are the sources of cellular energy for active...Ch. 3 - Checkpoint 15:
In what ways are endocytosis and...Ch. 3 - What are some of the chemicals present in cytosol?Ch. 3 - What is the function of cytosol?Ch. 3 - Define an organelle.Ch. 3 - Which organelles are surrounded by a membrane and...Ch. 3 - Checkpoint 20:
Which organelles contribute to...Ch. 3 - Checkpoint 21:
What happens on the cristae and in...Ch. 3 - Checkpoint 22:
How do large particles enter and...Ch. 3 - Where are ribosomes produced?Ch. 3 - Checkpoint 24:
How is DNA packed in the...Ch. 3 - Checkpoint 25:
What is meant by the term gene...Ch. 3 - What is the difference between transcription and...Ch. 3 - Distinguish between somatic and reproductive cell...Ch. 3 - What is the significance of interphase?Ch. 3 - Outline the major events of each stage of the...Ch. 3 - Prob. 30CPCh. 3 - How are haploid and diploid cells different?Ch. 3 - What axe homologous chromosomes?Ch. 3 - Prob. 33CPCh. 3 - What is one reason that some tissues become...Ch. 3 - CTQ 1: Mucin is a protein present in saliva and...Ch. 3 - CTQ 2: Sam does not consume alcohol, whereas his...Ch. 3 - CTQ 3: Marathon runners can become dehydrated due...
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