If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

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Chapter 29, Problem 4TYC

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If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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Answer 2

Question

Chapter 29, Problem 4TYC

Summary Introduction

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

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Answer 3

Question

Chapter 29, Problem 4TYC

Summary Introduction

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

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Answer 4

Question

Chapter 29, Problem 4TYC

Summary Introduction

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Expert Solution & Answer

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Answer 5

Chapter 29, Problem 4TYC

Summary Introduction

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Answer 6

Chapter 29, Problem 4TYC

Summary Introduction

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Answer 7

Chapter 29, Problem 4TYC

Summary Introduction

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Answer 8

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Answer 9

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Answer 11

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If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Solution Summary: The author explains how the ductus arteriosus failing to close after birth affects the neonatal blood pressure, systemic diastolic pressure and the heart.

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Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

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Chapter 29 Solutions

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Solution Summary: The author explains how the ductus arteriosus failing to close after birth affects the neonatal blood pressure, systemic diastolic pressure and the heart.

Videos

Summary: If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.

Want to see the full answer?

Chapter 29 Solutions

Summary:

If the ductus arteriosus fails to close after birth, the neonatal blood pressure, systemic diastolic pressure and the heart (right ventricle) are affected.