Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN: 9781133893943
Author: ESTRIDGE
Publisher: Cengage
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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-
expressed in normal cells?
a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function
b. mutant Grb2 protein that cannot bind to RTK
c. mutant RTK that lacks the extracellular domain
d. mutant PDK that has the PH domain but lost the kinase function
e. all of the above
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