CONNECT-W/ LEARNSMART LABS INQUIRY INTO
16th Edition
ISBN: 9781260482560
Author: Mader
Publisher: MCG
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Chapter 28.2, Problem 3LO
Explain how the Miller-Urey experiment (among others) provided support for the “primordial soup” hypothesis.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 28 Solutions
CONNECT-W/ LEARNSMART LABS INQUIRY INTO
Ch. 28.1 - Describe the contributions of Leeuwenhoek and...Ch. 28.1 - Prob. 2LOCh. 28.1 - Prob. 3LOCh. 28.1 - Prob. 1CYPCh. 28.1 - Prob. 2CYPCh. 28.1 - Prob. 3CYPCh. 28.2 - Distinguish between chemical and biological...Ch. 28.2 - Prob. 2LOCh. 28.2 - Explain how the Miller-Urey experiment (among...Ch. 28.2 - Prob. 4LO
Ch. 28.2 - Explain the role of biomolecules in chemical and...Ch. 28.2 - List the four stages of the evolution of life, and...Ch. 28.2 - Compare and contrast the “primordial soup” and the...Ch. 28.2 - Prob. 4CYPCh. 28.3 - List some of the major criteria that are used to...Ch. 28.3 - Prob. 2LOCh. 28.3 - Distinguish between halophiles, thermoacidophiles...Ch. 28.3 - Prob. 1CYPCh. 28.3 - Prob. 2CYPCh. 28.3 - 3. Describe adaptations that allow archaea to...Ch. 28.3 - Prob. 4CYPCh. 28.4 - Identify the major structural features of...Ch. 28.4 - Prob. 2LOCh. 28.4 - Explain why bacteria are considered to be...Ch. 28.4 - List several major bacterial diseases of humans...Ch. 28.4 - Prob. 1QTCCh. 28.4 - Prob. 2QTCCh. 28.4 - Prob. 3QTCCh. 28.4 -
1. Describe the three basic shapes of bacteria.
Ch. 28.4 - Explain how bacterial conjugation differs from...Ch. 28.4 - Prob. 3CYPCh. 28.4 - Prob. 4CYPCh. 28.5 - Prob. 1LOCh. 28.5 - Describe the steps in a typical viral reproductive...Ch. 28.5 - Prob. 3LOCh. 28.5 - Prob. 4LOCh. 28.5 - Prob. 1CYPCh. 28.5 - Prob. 2CYPCh. 28.5 - List three viral diseases for which a vaccine is...Ch. 28.5 - Prob. 4CYPCh. 28 - Prob. S1.2BYBCh. 28 - Sections 3.2 What are some basic structural...Ch. 28 - Prob. T27.1BYBCh. 28 - Decomposers Break down dead organic matter in the...Ch. 28 - Prob. 2ACh. 28 - Prob. 3ACh. 28 - Prob. 4ACh. 28 - Prob. 5ACh. 28 - While studying an ancient lake you discover that...Ch. 28 - Prob. 7ACh. 28 - Prob. 8ACh. 28 - Prob. 9ACh. 28 - Prob. 10ACh. 28 - Prob. 11ACh. 28 - 12. The Envelope of an animal virus is usually...Ch. 28 - Prob. 13ACh. 28 - Prob. 1TCCh. 28 - Prob. 2TCCh. 28 - Explain a method by which an antiviral drug could...Ch. 28 - Prob. 4TC
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