ANAT.+PHYS.LAB MANUAL-W/ACCESS >CUSTOM<
9th Edition
ISBN: 9781265357948
Author: SALADIN
Publisher: MCG CUSTOM
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Textbook Question
Chapter 28.1, Problem 2BYGO
How is the structure of the uterine tube mucosa related to its function?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
ANAT.+PHYS.LAB MANUAL-W/ACCESS >CUSTOM<
Ch. 28.1 - Prob. 1BYGOCh. 28.1 - How is the structure of the uterine tube mucosa...Ch. 28.1 - Prob. 3BYGOCh. 28.1 - Prob. 4BYGOCh. 28.1 - Prob. 1AYLOCh. 28.1 - What mature female structures arise from the...Ch. 28.1 - Prob. 3AYLOCh. 28.1 - General structure of ovarian follicles; their...Ch. 28.1 - Prob. 5AYLOCh. 28.1 - Prob. 6AYLO
Ch. 28.1 - Prob. 7AYLOCh. 28.1 - The tilt of the vagina and its relationship to...Ch. 28.1 - Prob. 9AYLOCh. 28.1 - Prob. 10AYLOCh. 28.1 - The prevalence of breast cancer; its diagnostic...Ch. 28.2 - Prob. 5BYGOCh. 28.2 - Prob. 6BYGOCh. 28.2 - Prob. 7BYGOCh. 28.2 - Prob. 1AYLOCh. 28.2 - Prob. 2AYLOCh. 28.2 - Thelarche, pubarche, and menarche as signs of...Ch. 28.2 - Prob. 4AYLOCh. 28.2 - Prob. 5AYLOCh. 28.2 - Ovarian and hormonal changes that bring on female...Ch. 28.2 - Prob. 7AYLOCh. 28.3 - Prob. 8BYGOCh. 28.3 - Prob. 9BYGOCh. 28.3 - Prob. 10BYGOCh. 28.3 - Describe what happens in the uterus during the...Ch. 28.3 - Describe the effects of FSH and LH on the ovary.Ch. 28.3 - Prob. 13BYGOCh. 28.3 - Prob. 1AYLOCh. 28.3 - Prob. 2AYLOCh. 28.3 - Prob. 3AYLOCh. 28.3 - Ways in winch meiosis in the female differs from...Ch. 28.3 - How far meiosis has progressed by the time the egg...Ch. 28.3 - Prob. 6AYLOCh. 28.3 - Prob. 7AYLOCh. 28.3 - Prob. 8AYLOCh. 28.3 - Prob. 9AYLOCh. 28.3 - Prob. 10AYLOCh. 28.3 - Prob. 11AYLOCh. 28.3 - Production, structure, function, and eventual...Ch. 28.3 - Four phases of the menstrual cycle; what happens...Ch. 28.4 - Prob. 14BYGOCh. 28.4 - Prob. 15BYGOCh. 28.4 - Prob. 16BYGOCh. 28.4 - Prob. 1AYLOCh. 28.4 - Physiological responses of orgasm and resolution...Ch. 28.5 - List the roles of HCG, estrogen, progesterone, and...Ch. 28.5 - Prob. 18BYGOCh. 28.5 - Prob. 19BYGOCh. 28.5 - Prob. 20BYGOCh. 28.5 - Prob. 21BYGOCh. 28.5 - Prob. 22BYGOCh. 28.5 - Prob. 1AYLOCh. 28.5 - Prob. 2AYLOCh. 28.5 - Prob. 3AYLOCh. 28.5 - Prob. 4AYLOCh. 28.5 - Prob. 5AYLOCh. 28.5 - Causes of morning sickness, constipation, and...Ch. 28.5 - Prob. 7AYLOCh. 28.5 - Prob. 8AYLOCh. 28.5 - Prob. 9AYLOCh. 28.5 - Prob. 10AYLOCh. 28.5 - Prob. 11AYLOCh. 28.5 - Prob. 12AYLOCh. 28.5 - Prob. 13AYLOCh. 28.5 - Prob. 14AYLOCh. 28.5 - Prob. 15AYLOCh. 28.6 - Prob. 23BYGOCh. 28.6 - Prob. 24BYGOCh. 28.6 - Prob. 25BYGOCh. 28.6 - Prob. 26BYGOCh. 28.6 - Prob. 27BYGOCh. 28.6 - Prob. 1AYLOCh. 28.6 - Prob. 2AYLOCh. 28.6 - Prob. 3AYLOCh. 28.6 - Prob. 4AYLOCh. 28.6 - Prob. 5AYLOCh. 28.6 - Prob. 6AYLOCh. 28.6 - Prob. 7AYLOCh. 28 - Prob. 1TYRCh. 28 - Prob. 2TYRCh. 28 - Prob. 3TYRCh. 28 - Prob. 4TYRCh. 28 - Prob. 5TYRCh. 28 - Prob. 6TYRCh. 28 - Prob. 7TYRCh. 28 - Prob. 8TYRCh. 28 - Prob. 9TYRCh. 28 - Prob. 10TYRCh. 28 - Prob. 11TYRCh. 28 - Prob. 12TYRCh. 28 - Prob. 13TYRCh. 28 - Prob. 14TYRCh. 28 - Prob. 15TYRCh. 28 - Prob. 16TYRCh. 28 - Prob. 17TYRCh. 28 - Prob. 18TYRCh. 28 - Prob. 19TYRCh. 28 - Prob. 20TYRCh. 28 - Prob. 1BYMVCh. 28 - Prob. 2BYMVCh. 28 - Prob. 3BYMVCh. 28 - Prob. 4BYMVCh. 28 - Prob. 5BYMVCh. 28 - Prob. 6BYMVCh. 28 - Prob. 7BYMVCh. 28 - Prob. 8BYMVCh. 28 - Prob. 9BYMVCh. 28 - Prob. 10BYMVCh. 28 - Prob. 1WWTSCh. 28 - Prob. 2WWTSCh. 28 - Prob. 3WWTSCh. 28 - Prob. 4WWTSCh. 28 - Prob. 5WWTSCh. 28 - Prob. 6WWTSCh. 28 - Prob. 7WWTSCh. 28 - Prob. 8WWTSCh. 28 - Prob. 9WWTSCh. 28 - Prob. 10WWTSCh. 28 - Prob. 1TYCCh. 28 - Prob. 2TYCCh. 28 - Prob. 3TYCCh. 28 - Prob. 4TYCCh. 28 - Prob. 5TYC
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