EBK BIOLOGY
EBK BIOLOGY
11th Edition
ISBN: 9780134226453
Author: Byers
Publisher: PEARSON
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Chapter 28, Problem 4MC
Summary Introduction

Introduction:

An increase in population size is dependent on several different factors. Factors such as environmental resistance, resource availability, fertility rate, technological and medical advances, economic development, etc., are responsible for increase or decrease in population size. Population pyramids can provide an estimation of the trend of increasing or decreasing population sizes.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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