FUNDAMENTALS OF ANATOMY AND PHYSIOLOGY
11th Edition
ISBN: 2818440070938
Author: Martini
Publisher: PEARSON C
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Chapter 28, Problem 25RQ
Summary Introduction
To determine:
The location where endometrial cells become established and the reason of periodic pain occurs during endometriosis.
Introduction:
Endometriosis is a disorder in which the tissue that normally present inside the uterus that lines them grows outside of it. It leads to endometrial implants formation.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
FUNDAMENTALS OF ANATOMY AND PHYSIOLOGY
Ch. 28 - Define gamete.Ch. 28 - List the basic structures of the reproductive...Ch. 28 - Define gonads.Ch. 28 - Name the male reproductive structures.Ch. 28 - Prob. 5CPCh. 28 - Trace the pathway that a sperm travels from the...Ch. 28 - What effect would a low FSH level have on sperm...Ch. 28 - Prob. 8CPCh. 28 - Prob. 9CPCh. 28 - Prob. 10CP
Ch. 28 - Prob. 11CPCh. 28 - Prob. 12CPCh. 28 - Prob. 13CPCh. 28 - Prob. 14CPCh. 28 - What event in the uterine cycle occurs when the...Ch. 28 - Prob. 16CPCh. 28 - Prob. 17CPCh. 28 - Prob. 18CPCh. 28 - Prob. 19CPCh. 28 - What structure in a sexually indifferent embryo...Ch. 28 - Prob. 21CPCh. 28 - Define menopause.Ch. 28 - Why does the level of FSH increase and remain high...Ch. 28 - Describe the interaction between the reproductive...Ch. 28 - Describe the interaction between the reproductive...Ch. 28 - Prob. 1RQCh. 28 - The ovaries are responsible tor (a) the production...Ch. 28 - In females, meiosis II is not completed until (a)...Ch. 28 - A sudden surge in LH secretion causes the (a)...Ch. 28 - The main hormone of the postovulatory phase is (a)...Ch. 28 - Prob. 6RQCh. 28 - Prob. 7RQCh. 28 - Prob. 8RQCh. 28 - Prob. 9RQCh. 28 - Prob. 10RQCh. 28 - Prob. 11RQCh. 28 - Prob. 12RQCh. 28 - Trace the path of milk flow from its site of...Ch. 28 - Prob. 14RQCh. 28 - Prob. 15RQCh. 28 - Prob. 16RQCh. 28 - What are the main differences in gamete production...Ch. 28 - Prob. 18RQCh. 28 - Describe each of the three phases of a typical...Ch. 28 - Prob. 20RQCh. 28 - Prob. 21RQCh. 28 - Prob. 22RQCh. 28 - Prob. 23RQCh. 28 - Diane has peritonitis (an inflammation of the...Ch. 28 - Prob. 25RQCh. 28 - Birth control pills contain estradiol and...Ch. 28 - Female bodybuilders and women with eating...Ch. 28 - Prob. 1CCCh. 28 - When should Susan expect ovulation to occur during...
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