EP CONNECT ONLINE ACCESS FOR BIOLOGY
EP CONNECT ONLINE ACCESS FOR BIOLOGY
20th Edition
ISBN: 9781260494655
Author: Raven
Publisher: MCG COURSE
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Chapter 27, Problem 3S

Use of multiple antibiotics is not a bad idea if ill of the bacteria are killed. In the case of sane persistent infections, this is an effective strategy. However, it does provide very strong selective pressure for rare genetic events that procure multiple resistances in a single bacterial species. For this reason, it is not a good idea for it be the normal practice The more bacteria that undergo this election for multiple resistance, the more likely a will arise. This is helped by patients not taking their entire course of antibiotic because bacteria may survive by chance and proliferate, with each generation providing the opportunity for new mutations. This is also complicated by the horizontal transfer of resistance via resistance plasmids, and by the existence of transposable genetic elements that can move genes from one piece of DMA to another.

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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid is located on the outside of the soluble protein but not near an active site. O-H¨ A. What type of mutation occurred? O-H B. What 2 types of chemical bonds are found in the R-groups of each amino acid? The R groups are shaded. CH2 CH2 CH2 H2N-C-COOH H2N-C-COOH 1 H Glutamic acid H Aspartic acid C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules? D. Consider the chemical properties of the two amino acids and the location of the amino acid in the protein. Explain what effect this mutation will have on this protein's function and why.
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