EP ORGANIC CHEMISTRY-OWL V2 ACCESS
8th Edition
ISBN: 9781305582453
Author: Brown
Publisher: Cengage Learning
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Chapter 26.6, Problem AQ
Interpretation Introduction
Interpretation:
Among the given statements, one challenge to understand the carboxylation of glutamate side chain in biological setting has to be identified.
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Which of the following is a challenge to understanding how the carboxylation of glutamate side chains is feasible in a biological setting?
1. Because the pKa of the a-hydrogen of glutamate is 27, it is too high to be effectively deprotonated at physiological pH.
2. The C-C bond formed in a 1,3-dicarboxylate is too weak to exist in a biological setting.
3. b-Dicarboxylic acids spontaneously decarboxylate at neutral pH.
4. Both 1 and 3.
From which amino acid are serotonin and melatonin synthesized? What types of reac-
tions are involved in their biosynthesis?
HO,
CH,CH,NH,
CH,O,
CH,CH,NHCCH,
(a)
(b)
H
Serotonin
Melatonin
The pathway for nicotinic acid requires a series of highly unfavorable reactions. Which other alkaloid molecular scaffold would you use to arrive to such a molecule? And, which series of hypothetical enzymes would you use?
Chapter 26 Solutions
EP ORGANIC CHEMISTRY-OWL V2 ACCESS
Ch. 26.1 - Prob. 26.1PCh. 26.6 - Prob. AQCh. 26.6 - Prob. BQCh. 26.6 - Prob. CQCh. 26.6 - Prob. DQCh. 26.6 - Prob. FQCh. 26 - Prob. 26.2PCh. 26 - Identify the hydrophobic and hydrophilic region(s)...Ch. 26 - Prob. 26.4PCh. 26 - Prob. 26.5P
Ch. 26 - Prob. 26.6PCh. 26 - Prob. 26.7PCh. 26 - Prob. 26.8PCh. 26 - Prob. 26.9PCh. 26 - How many moles of H2 are used in the catalytic...Ch. 26 - Prob. 26.11PCh. 26 - Prob. 26.12PCh. 26 - Prob. 26.13PCh. 26 - Prob. 26.14PCh. 26 - Prob. 26.15PCh. 26 - Prob. 26.16PCh. 26 - Prob. 26.17PCh. 26 - Prob. 26.18PCh. 26 - Prob. 26.20PCh. 26 - Prob. 26.21PCh. 26 - Prob. 26.22PCh. 26 - Prob. 26.23PCh. 26 - Following is a structural formula for cortisol...Ch. 26 - Prob. 26.25PCh. 26 - Draw the structural formula of a lecithin...Ch. 26 - Prob. 26.27PCh. 26 - Prob. 26.28PCh. 26 - Prob. 26.29PCh. 26 - Prob. 26.30PCh. 26 - Prob. 26.31PCh. 26 - Prob. 26.32PCh. 26 - Prob. 26.33P
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