Biology: Concepts and Investigations
4th Edition
ISBN: 9780078024207
Author: Mariëlle Hoefnagels Dr.
Publisher: McGraw-Hill Education
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Chapter 25.1, Problem 1MC
What is the difference between anatomy an d physiology?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 25 Solutions
Biology: Concepts and Investigations
Ch. 25.1 - What is the difference between anatomy an d...Ch. 25.1 - What is the relationship among cells, tissues,...Ch. 25.1 - Trace the bodys early development from one...Ch. 25.2 - If you were given a microscope slide with a slice...Ch. 25.2 - Suppose you determine that a tissue sample...Ch. 25.3 - Which organ systems contribute to each of the five...Ch. 25.3 - Prob. 2MCCh. 25.4 - Use figure 25.9 to explain which materials enter...Ch. 25.4 - Prob. 2MCCh. 25.4 - Prob. 3MC
Ch. 25.5 - How does the integumentary system help the body...Ch. 25.5 - Prob. 2MCCh. 25.6 - Prob. 1MCCh. 25.6 - Suggest a specific prediction related to folic...Ch. 25 - Which of the following represents the correct...Ch. 25 - According to the anatomical terms in figure 25.3,...Ch. 25 - Epithelial tissue consisting of multiple layers of...Ch. 25 - Which of the following features do all types of...Ch. 25 - Prob. 5MCQCh. 25 - Ovaries produce gametes and hormones; these organs...Ch. 25 - Prob. 7MCQCh. 25 - The inner layer of skin is __________, whereas the...Ch. 25 - How does the integumentary system influence...Ch. 25 - Distinguish between the following. a. Organs and...Ch. 25 - Use the Internet to research cosmetic surgery....Ch. 25 - Prob. 3WIOCh. 25 - Explain the similarities and differences among the...Ch. 25 - Explain how you use your organ systems (except...Ch. 25 - Describe how the circulatory system connects the...Ch. 25 - Prob. 7WIOCh. 25 - Prob. 8WIOCh. 25 - Describe at least one interaction between skin and...Ch. 25 - 1. What features distinguish the four types of...Ch. 25 - Prob. 2PITCh. 25 - Review the Survey the Landscape figure in the...
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