Why there is a difference in yield when alanine and valine is prepared via amidomalonate synthesis need to be explained. Concept introduction: Amidomalonate synthesis is a process in which a halide is converted to a aminoacid with two new carbon atoms (comes from amidomalonate). By use of this method a new alkyl groups can be introduced. A general scheme of this synthesis is shown below, Steps involved in amidomalonater synthesis are, Deprotonation of α carbon in amidomalonate Alkylation of enolate Hydrolysis of ester using aqueous acid Decarboxylation at high temperature Please remember that if the primary alkyl halide reactivity is more than secondary alkyl halide due to less steric hindrance.

Question

Want to see the full answer?

Answer 1

Question

Chapter 25, Problem 57PP

Interpretation Introduction

Interpretation:

Why there is a difference in yield when alanine and valine is prepared via amidomalonate synthesis need to be explained.

Concept introduction:

Amidomalonate synthesis is a process in which a halide is converted to a aminoacid with two new carbon atoms (comes from amidomalonate). By use of this method a new alkyl groups can be introduced. A general scheme of this synthesis is shown below,

Steps involved in amidomalonater synthesis are,

Deprotonation of α carbon in amidomalonate

Alkylation of enolate

Hydrolysis of ester using aqueous acid

Decarboxylation at high temperature

Please remember that if the primary alkyl halide reactivity is more than secondary alkyl halide due to less steric hindrance.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

when performing the reaction that involves 2 equivalents of 3-(diethylamino)-phenol and Phthalic anhydride with sulfuric acid and water react to form rhodamine b where the Phthalic anhydride cleaves in acid and how does Excessive Washing (w/ Base) & Subsequent Resonance Structure get affected

3. The strongest acid of the following compounds is ___.A. p-nitrophenol; B. m-nitrophenol; C. o-chlorophenol;D. p-methoxyphenol; E. o-methylphenol Please explain your steps and thought process. Thank you!

Using the general properties of equilibrium constants At a certain temperature, the equilibrium constant K for the following reaction is 1.3 × 10 4: Cl2(g) + CHCl3(g) HCl(g) + CC₁(g) Use this information to complete the following table. Suppose a 16. L reaction vessel is filled with 1.6 mol of HCI and 1.6 mol of CCl4. What can you say about the composition of the mixture in the vessel at equilibrium? There will be very little Cl2 and CHCl3. ☐ x10 There will be very little HCI and CCl4. Neither of the above is true. What is the equilibrium constant for the following reaction? Be sure your answer has the correct number of significant digits. HCl(g)+CC14(g) 12 Cl2(9)+CHCl3(9) K = 0 ☐ What is the equilibrium constant for the following reaction? Be sure your answer has the correct number of significant digits. 2 Cl₂(9)+2CHCl3(9) 2 HCl(9)+2CC₁₁(9) K = ✓ 00. 18 Ar