Alkylation of cysteine258 substituted aspartate aminotransferase gives some enzymatic activity. Concept introduction: Aspartate aminotransferase (AST) enzyme is found in all the cells of the body, mostly in heart and liver cells. This enzyme is very important in amino acid metabolism because it catalyzes the interconversion of aspartate and glutamate. During the conversion of a-ketoglutarate to glutamate, glutamate undergoes deamination t form ammonium. Reversely, aspartate is formed from OAA, which is used in the Krebs cycle.

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Chapter 24, Problem 25P

Interpretation Introduction

Interpretation:

Alkylation of cysteine258 substituted aspartate aminotransferase gives some enzymatic activity.

Concept introduction:

Aspartate aminotransferase (AST) enzyme is found in all the cells of the body, mostly in heart and liver cells. This enzyme is very important in amino acid metabolism because it catalyzes the interconversion of aspartate and glutamate. During the conversion of a-ketoglutarate to glutamate, glutamate undergoes deamination t form ammonium. Reversely, aspartate is formed from OAA, which is used in the Krebs cycle.

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