ANATOMY PHYS VOL II W ACCESS  CUSTOM
ANATOMY PHYS VOL II W ACCESS CUSTOM
9th Edition
ISBN: 9781264412303
Author: SALADIN
Publisher: MCG CUSTOM
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Chapter 23.3, Problem 7AYLO

How the myogenic mechanism of renal autoregulation works

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Digoxin: Intravenous Bolus - Two Compartment Model Drug Digoxin Route: IV Bolus Dose: 0.750 mg Plasma Concentration Time Profile Beta Alpha Time (hrs) Conc (ng/ml) LN (ng/ml) LN (ng/ml) LN 0.00 #NUM! #NUM! #NUM! 0.10 12.290 2.509 #NUM! #NUMI 0.60 6.975 1.942 #NUM! #NUMI 1.00 4.649 1.537 #NUM! #NUMI 2.00 2.201 0.789 #NUM! #NUM! 3.00 1.536 0.429 #NUM! #NUM! 4.00 1.342 0.294 #NUM! #NUM! 5.00 1.273 0.241 #NUM! #NUMI 6.00 1.238 0.213 #NUM! #NUM! 7.00 1.212 0.192 #NUM! #NUM! 8.00 1.188 0.172 #NUMI #NUM! 9.00 1.165 0.153 #NUM! #NUMI 10.00 1.143 0.134 #NUMI #NUM! 11.00 1.122 0.115 #NUM! 12.00 1.101 0.096 #NUMI 13.00 1.080 0.077 #NUMI 16.00 1.020 0.020 #NUMI 24.00 0.876 -0.132 #NUMI Pharmacokinetic Parameters Parameter Value Alpha B Beta Units ng/ml hr-1 ng/ml hr-1 CO ng/ml H.C AUC ng x hr/ml Vc Vbeta Vss C L/hr TK (alpha) hr TX (beta) days 5+ F3 F4 F5 0+ F6 F7 % 6 95 14 #3 29 & t F8 F9 FW EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg rabbits following a bolus IV injection of 10mg/kg. Time (minutes) Serum Linuron Levels (ug/ml) following IV dose 10 15.48 20 8.60 30 5.90 45 3.78 60 2.42 90 1.49 120 0.93 180 0.60 240 0.41 300 0.29 360 0.22 Analyze this data and perform the necessary calculations to determine the following pharmacokinetic parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points possible). You do NOT need to submit graphs or data tables. Give the terminal regression line equation and R or R² value: Give the x axis (name and units, if any) of the terminal line: Give the y axis (name and units, if any) of the terminal line: Give the residual regression line equation and R or R² value: Give the x axis (name and units, if any) of the residual line: Give the y axis (name and units, if any) of the residual line:

Chapter 23 Solutions

ANATOMY PHYS VOL II W ACCESS CUSTOM

Ch. 23.2 - Prob. 6BYGOCh. 23.2 - Prob. 1AYLOCh. 23.2 - Prob. 2AYLOCh. 23.2 - Three layers of tissue that surround and...Ch. 23.2 - Prob. 4AYLOCh. 23.2 - Prob. 5AYLOCh. 23.2 - Prob. 6AYLOCh. 23.2 - Prob. 7AYLOCh. 23.2 - Prob. 8AYLOCh. 23.2 - Prob. 9AYLOCh. 23.2 - Prob. 10AYLOCh. 23.2 - Prob. 11AYLOCh. 23.2 - Prob. 12AYLOCh. 23.3 - Prob. 7BYGOCh. 23.3 - Prob. 8BYGOCh. 23.3 - Prob. 9BYGOCh. 23.3 - Prob. 10BYGOCh. 23.3 - Prob. 1AYLOCh. 23.3 - Prob. 2AYLOCh. 23.3 - Prob. 3AYLOCh. 23.3 - Prob. 4AYLOCh. 23.3 - Prob. 5AYLOCh. 23.3 - Prob. 6AYLOCh. 23.3 - How the myogenic mechanism of renal autoregulation...Ch. 23.3 - Structure and function of the juxtaglomerular...Ch. 23.3 - Prob. 9AYLOCh. 23.3 - Prob. 10AYLOCh. 23.3 - Prob. 11AYLOCh. 23.4 - The reabsorption of water, Cl-, and glucose by the...Ch. 23.4 - Prob. 12BYGOCh. 23.4 - Prob. 13BYGOCh. 23.4 - Prob. 1AYLOCh. 23.4 - Prob. 2AYLOCh. 23.4 - Prob. 3AYLOCh. 23.4 - Prob. 4AYLOCh. 23.4 - Prob. 5AYLOCh. 23.4 - Prob. 6AYLOCh. 23.4 - Prob. 7AYLOCh. 23.5 - Prob. 14BYGOCh. 23.5 - Prob. 15BYGOCh. 23.5 - Prob. 16BYGOCh. 23.5 - Prob. 1AYLOCh. 23.5 - Prob. 2AYLOCh. 23.5 - Prob. 3AYLOCh. 23.5 - Function of the countercurrent multiplier and how...Ch. 23.5 - Prob. 5AYLOCh. 23.6 - Prob. 17BYGOCh. 23.6 - Prob. 18BYGOCh. 23.6 - Prob. 19BYGOCh. 23.6 - Prob. 20BYGOCh. 23.6 - Prob. 1AYLOCh. 23.6 - Prob. 2AYLOCh. 23.6 - Prob. 3AYLOCh. 23.6 - Prob. 4AYLOCh. 23.6 - Prob. 5AYLOCh. 23.6 - Prob. 6AYLOCh. 23.6 - Prob. 7AYLOCh. 23.6 - Prob. 8AYLOCh. 23.7 - Prob. 21BYGOCh. 23.7 - Prob. 22BYGOCh. 23.7 - Prob. 23BYGOCh. 23.7 - The route and mechanism of urine transport from...Ch. 23.7 - Prob. 2AYLOCh. 23.7 - Prob. 3AYLOCh. 23.7 - Anatomy of the male urethra, its three segments,...Ch. 23.7 - The mechanism of the spinal micturition reflex and...Ch. 23.7 - Prob. 6AYLOCh. 23 - Prob. 1TYRCh. 23 - The compact ball of capillaries in a nephron is...Ch. 23 - Prob. 3TYRCh. 23 - Prob. 4TYRCh. 23 - Most sodium is reabsorbed from the glomerular...Ch. 23 - Prob. 6TYRCh. 23 - Prob. 7TYRCh. 23 - Prob. 8TYRCh. 23 - Beavers have relatively little need to conserve...Ch. 23 - Prob. 10TYRCh. 23 - Prob. 11TYRCh. 23 - _______ is the ability of a nephron to adjust its...Ch. 23 - The two ureters and the urethra form the...Ch. 23 - The _______ is a group of epithelial cells of the...Ch. 23 - To enter the capsular space, filtrate must pass...Ch. 23 - Glycosuria occurs if the rate of glomerular...Ch. 23 - Prob. 17TYRCh. 23 - Prob. 18TYRCh. 23 - Prob. 19TYRCh. 23 - Prob. 20TYRCh. 23 - Prob. 1BYMVCh. 23 - Prob. 2BYMVCh. 23 - Prob. 3BYMVCh. 23 - Prob. 4BYMVCh. 23 - Prob. 5BYMVCh. 23 - Prob. 6BYMVCh. 23 - Prob. 7BYMVCh. 23 - Prob. 8BYMVCh. 23 - pyelo-Ch. 23 - Prob. 10BYMVCh. 23 - Prob. 1WWTSCh. 23 - Prob. 2WWTSCh. 23 - Prob. 3WWTSCh. 23 - Tight junctions prevent material from leaking...Ch. 23 - Prob. 5WWTSCh. 23 - Prob. 6WWTSCh. 23 - Prob. 7WWTSCh. 23 - The minimum osmolarity of urine is 300 mOsm/L,...Ch. 23 - Prob. 9WWTSCh. 23 - Prob. 10WWTSCh. 23 - Prob. 1TYCCh. 23 - Prob. 2TYCCh. 23 - Prob. 3TYCCh. 23 - Drugs called renin inhibitors are used to treat...Ch. 23 - Prob. 5TYC
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