EBK MICROBIOLOGY
12th Edition
ISBN: 8220100659720
Author: CASE
Publisher: PEARSON
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Chapter 23, Problem 4R
Complete the following table.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 23 Solutions
EBK MICROBIOLOGY
Ch. 23 - Identify the portals of entry for Trypanosoma...Ch. 23 - Prob. 2RCh. 23 - Prob. 3RCh. 23 - Complete the following table.Ch. 23 - Complete the following table.Ch. 23 - Prob. 6RCh. 23 - Compare and contrast cat-scratch disease and...Ch. 23 - Prob. 8RCh. 23 - Prob. 9RCh. 23 - Prob. 10R
Ch. 23 - Use the following choices to answer questions 1...Ch. 23 - Prob. 2MCQCh. 23 - Prob. 3MCQCh. 23 - Prob. 4MCQCh. 23 - Prob. 5MCQCh. 23 - Which of the following is not a tickborne disease?...Ch. 23 - Prob. 7MCQCh. 23 - Prob. 8MCQCh. 23 - Prob. 9MCQCh. 23 - Prob. 10MCQCh. 23 - Prob. 1ACh. 23 - What is the most effective way to control malaria...Ch. 23 - Prob. 3ACh. 23 - The hunter picked up the front paws for good luck....Ch. 23 - Prob. 2CAECh. 23 - Prob. 3CAECh. 23 - Prob. 4CAECh. 23 - A 67-year-old man worked in a textile mill that...
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