To compare: The five major classes of infectious agents. Concept introduction: Infectious organisms are the harmful agents that are capable of causing damage or death to the organism that they invade. These organisms are termed as pathogenic organisms as they cause harmful effects in the host system. There are five major classes of infectious agents that cause diseases in the humans, including bacteria, virus, fungi , protozoan, and multicellular parasites .

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Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 22.1, Problem 1LO

Summary Introduction

To compare: The five major classes of infectious agents.

Concept introduction: Infectious organisms are the harmful agents that are capable of causing damage or death to the organism that they invade. These organisms are termed as pathogenic organisms as they cause harmful effects in the host system. There are five major classes of infectious agents that cause diseases in the humans, including bacteria, virus, fungi, protozoan, and multicellular parasites.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

Answer 2

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Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 22.1, Problem 1LO

Summary Introduction

To compare: The five major classes of infectious agents.

Concept introduction: Infectious organisms are the harmful agents that are capable of causing damage or death to the organism that they invade. These organisms are termed as pathogenic organisms as they cause harmful effects in the host system. There are five major classes of infectious agents that cause diseases in the humans, including bacteria, virus, fungi, protozoan, and multicellular parasites.

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Answer 3

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Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 22.1, Problem 1LO

Summary Introduction

To compare: The five major classes of infectious agents.

Concept introduction: Infectious organisms are the harmful agents that are capable of causing damage or death to the organism that they invade. These organisms are termed as pathogenic organisms as they cause harmful effects in the host system. There are five major classes of infectious agents that cause diseases in the humans, including bacteria, virus, fungi, protozoan, and multicellular parasites.

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Check out a sample textbook solution

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Answer 4

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Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

Chapter 22.1, Problem 1LO

Summary Introduction