Chapter 22, Problem 8P

Interpretation Introduction

Interpretation:

If a replication DNA polymerase had its $3^{\text{'}}\text{exonuclease}$ site $1.5\text{ nm}$ from polymerase site, instead of $3.0\text{ nm}$, the effect of this change in the fidelity of the enzyme should be explained. An additional change that can provide the enzyme with the same fidelity should be described.

Concept Introduction:

Polymerase is the enzyme that helps in the synthesis of nucleic acid polymers. The polymerase enzyme copies the RNA and DNA template using base-pairing techniques.