Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 22, Problem 4PDQ
One of the major causes of sickness, death, and economic loss in the cattle industry is Mannheimia haemolytiea, which causes bovine pasteurellosis, or shipping fever. Non invasive delivery of a vaccine using transgenic plants expressing immunogens would reduce labor costs and trauma to livestock. An early step toward developing an edible vaccine is to determine whether an injected version of an antigen (usually a derivative of the pathogen) is capable of stimulating the development of antibodies in a test organism. The following table assesses the ability of a transgenic portion of a toxin (Lkt) of M. haemolytiea to stimulate development of specific antibodies in rabbits.
* Lkt50 is a smaller derivative of Lkt that lacks all hydrophobic regions. + indicates at least 50 percent neutralization of toxicity of Lkt; − indicates no neutralization activity.
Source: Modified from Lee et al. (2001). Infect. and Immunity 69:5786-5793.
- (a) What general conclusion can you draw from the data?
- (b) With regards to development of a usable edible vaccine, what work remains to be done?
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Chapter 22 Solutions
Concepts of Genetics (12th Edition)
Ch. 22 - In order to vaccinate people against diseases by...Ch. 22 - Prob. 2NSTCh. 22 - Prob. 1CSCh. 22 - Prob. 2CSCh. 22 - Prob. 3CSCh. 22 - HOW DO WE KNOW? In this chapter, we focused on a...Ch. 22 - Prob. 2PDQCh. 22 - Why are most recombinant human proteins produced...Ch. 22 - One of the major causes of sickness, death, and...Ch. 22 - Sequencing the human genome, the development of...
Ch. 22 - Prob. 6PDQCh. 22 - As genetic testing becomes widespread, medical...Ch. 22 - Prob. 8PDQCh. 22 - Prob. 9PDQCh. 22 - Does genetic analysis by ASO testing allow for...Ch. 22 - Maternal blood tests for three pregnant women...Ch. 22 - What is the main purpose of genome-wide...Ch. 22 - Describe how the team from the J. Craig Venter...Ch. 22 - Prob. 14PDQCh. 22 - Prob. 15PDQCh. 22 - Dominant mutations can be categorized according to...Ch. 22 - In 2013 the actress Angelina Jolie elected to have...Ch. 22 - Prob. 18PDQCh. 22 - Should the FDA regulate direct-to-consumer genetic...Ch. 22 - Prob. 20ESPCh. 22 - Following the tragic shooting of 20 children at a...Ch. 22 - Private companies are offering personal DNA...Ch. 22 - Prob. 23ESPCh. 22 - Prob. 24ESPCh. 22 - Prob. 25ESPCh. 22 - Craig Venter and others have constructed synthetic...
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