
Concept explainers
(a)
Interpretation:
The reaction catalyzed by enzyme citrate synthase has to be described.
Concept Introduction:
The enzymes are essentially the biocatalysts present in all living systems. Each enzyme catalyzes a characteristic reaction within the biological system. Enzymes are generally named in accordance with the substrate on which they act. For example, enzyme urease is named by the addition of the suffix–ase to the name of the substrate urea on which this enzyme acts. Similarly, the enzyme sucrase derives its name from sucrose as it hydrolyzes the linkages of sucrose to yield fructose and glucose monomers of disaccharide sucrose.
Based on their specific role and the specific reaction they catalyze enzymes are classified into six major classes. These are as follows:
- Ligases: The enzymes that connect two molecules via covalent bonds are termed as ligases. DNA ligase is one such enzyme.
- Isomerases: The enzymes that catalyze the isomerization reactions are termed as isomerases. For example, triosephosphate isomerase.
- Lyases: The enzymes that catalyze the cleavage of bonds are called lyases. Enzyme fumarase belongs to this category as they cleave the carbon-oxygen bond of malate to convert it reversibly into fumarate.
- Hydrolases: These enzymes catalyze the cleavage of bonds via hydrolysis present in biological systems. Lipase is one such enzyme.
- Transferases: These enzymes are involved in the transfer of various
functional groups such as methyl, acetyl group, or phosphate group. Alanine transaminase is one such enzyme. - Oxidoreductases: As the name suggests, these catalyze the
oxidation and reduction reactions that occur in living systems. Succinate dehydrogenase is an example of oxidoreductase.
(b)
Interpretation:
The reaction catalyzed by enzyme aconitase has to be described.
Concept Introduction:
Refer to part (a)
(c)
Interpretation:
The reaction catalyzed by enzyme isocitrate dehydrogenase has to be described.
Concept Introduction:
Refer to part (a)
(d)
Interpretation:
The reaction catalyzed by enzyme
Concept Introduction:
Refer to part (a)
(e)
Interpretation:
The reaction catalyzed by enzyme succinyl CoA synthase has to be described.
Concept Introduction:
Refer to part (a)
(f)
Interpretation:
The reaction catalyzed by enzyme succinate dehydrogenase has to be described.
Concept Introduction:
Refer to part (a)
(g)
Interpretation:
The reaction catalyzed by enzyme fumarase has to be described.
Concept Introduction:
Refer to part (a)
(h)
Interpretation:
The reaction catalyzed by enzyme malate has to be described.
Concept Introduction:
Refer to part (a)

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Chapter 22 Solutions
General, Organic, and Biochemistry
- Curved arrows are used to illustrate the flow of electrons. Using the provided starting anand product sytucutrs, draw the curved electron-pusing arrows for the following reaction or mechanistic steps. Be sure to account for all bond-breaking and bind-making stepsarrow_forwardDraw the major elimination and substitution products formed in this reavtion. Use a dash or wedge bond to indicatr the stereochemistry of substituents on assymetric centers, wheere applicable. Ignore any inorganic byproducts.arrow_forwardDraw the two possible products produced in this E2 elimination. Ignore any inorganic byproductsarrow_forward
- Draw the major products of this SN1 reaction. Ignore any inorganic byproducts.arrow_forwardDraw the major elimination and substitution products formed in this reaction. Use a dash or wedge bond to indicate the stereochemistry of substituents on asymmetric centers, wehre applicable. Ignore and inorganic byproducts.arrow_forwardCurved arrows are used to illustrate the flow of electrons. Using the provided starting and product structures, draw the curved electron-pushing arrows for the following reaction or mechanistic step(s). Be sure to account for all bond-breaking and bond-making steps. Drawing Arrows THE Problem 33 of 35 N. C:0 Na + Submit Drag To Pan +arrow_forward
- Draw the product of the E2 reaction shown below. Include the correct stereochemistry. Ignore and inorganic byproducts.arrow_forwardDraw the major producrs of this SN1 reaction. Ignore any inorganic byproducts. Use a dash or wedge bond to indicate the sereochemistry of substituents on asymmetric centers where appllicable.arrow_forward5) Oxaloacetic Acid is an important intermediate in the biosynthesis of citric acid. Synthesize oxaloacetic acid using a mixed Claisen Condensation reaction with two different esters and a sodium ethoxide base. Give your answer as a scheme Hint 1: Your final acid product is producing using a decarboxylation reaction. Hint 2: Look up the structure of oxalic acid. HO all OH oxaloacetic acidarrow_forward
- 20. The Brusselator. This hypothetical system was first proposed by a group work- ing in Brussels [see Prigogine and Lefever (1968)] in connection with spatially nonuniform chemical patterns. Because certain steps involve trimolecular reac tions, it is not a model of any real chemical system but rather a prototype that has been studied extensively. The reaction steps are A-X. B+X-Y+D. 2X+ Y-3X, X-E. 305 It is assumed that concentrations of A, B, D, and E are kept artificially con stant so that only X and Y vary with time. (a) Show that if all rate constants are chosen appropriately, the equations de scribing a Brusselator are: dt A-(B+ 1)x + x²y, dy =Bx-x²y. diarrow_forwardProblem 3. Provide a mechanism for the following transformation: H₂SO A Me. Me Me Me Mearrow_forwardYou are trying to decide if there is a single reagent you can add that will make the following synthesis possible without any other major side products: xi 1. ☑ 2. H₂O хе i Draw the missing reagent X you think will make this synthesis work in the drawing area below. If there is no reagent that will make your desired product in good yield or without complications, just check the box under the drawing area and leave it blank. Click and drag to start drawing a structure. There is no reagent that will make this synthesis work without complications. : ☐ S ☐arrow_forward
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