Hole's Human Anatomy & Physiology
15th Edition
ISBN: 9781259864568
Author: SHIER, David, Butler, Jackie, Lewis, Ricki
Publisher: Mcgraw-hill Education,
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Chapter 22, Problem 14P
Where is the prostate gland located?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 22 Solutions
Hole's Human Anatomy & Physiology
Ch. 22 - Prob. 1PCh. 22 - Prob. 2PCh. 22 - Prob. 3PCh. 22 - Prob. 4PCh. 22 - Prob. 5PCh. 22 - Where in the testes are sperm cells produced?Ch. 22 - Which cells produce male sex hormones?Ch. 22 - Review the events of spermatogenesis.Ch. 22 - Explain the function of the sustentacular cells in...Ch. 22 - Prob. 10P
Ch. 22 - Describe the structure of the epididymis.Ch. 22 - Trace the path of the ductus deferns.Ch. 22 - What is the function of a seminal vesicle?Ch. 22 - Where is the prostate gland located?Ch. 22 - What is the function of the bulbourethral glands?Ch. 22 - Prob. 16PCh. 22 - Prob. 17PCh. 22 - Prob. 18PCh. 22 - Prob. 19PCh. 22 - Distinguish among orgasm, emission, and...Ch. 22 - Prob. 21PCh. 22 - Prob. 22PCh. 22 - Prob. 23PCh. 22 - Explain how the secretion of male sex hormones is...Ch. 22 - Prob. 25PCh. 22 - Prob. 26PCh. 22 - Prob. 27PCh. 22 - Prob. 28PCh. 22 - Prob. 29PCh. 22 - Prob. 30PCh. 22 - Prob. 31PCh. 22 - Prob. 32PCh. 22 - Prob. 33PCh. 22 - Prob. 34PCh. 22 - Prob. 35PCh. 22 - Prob. 36PCh. 22 - What is the male counterpart of the labia majora?...Ch. 22 - Prob. 38PCh. 22 - Prob. 39PCh. 22 - Prob. 40PCh. 22 - Prob. 41PCh. 22 - Prob. 42PCh. 22 - Prob. 43PCh. 22 -
44 What are the function of estrogens?
Ch. 22 - Prob. 45PCh. 22 - Trace the events of the female reproductive cycle.Ch. 22 - Prob. 47PCh. 22 - Prob. 48PCh. 22 - Prob. 49PCh. 22 - Prob. 50PCh. 22 - Prob. 51PCh. 22 - Prob. 52PCh. 22 - Describe two methods of contraception that use...Ch. 22 - Prob. 54PCh. 22 - Prob. 55PCh. 22 - Prob. 56PCh. 22 - Prob. 57PCh. 22 - Prob. 58PCh. 22 - Prob. 59PCh. 22 - What are some common symptoms of diseases...Ch. 22 - Prob. 1CACh. 22 - Prob. 2CACh. 22 - Prob. 3CACh. 22 - Prob. 4CACh. 22 - Prob. 5CACh. 22 - Prob. 6CACh. 22 - Explain the function of the sustentacular cells in...Ch. 22 - Prob. 8CACh. 22 - Describe a sperm cell. (p. 829)Ch. 22 - Prob. 10CACh. 22 - Prob. 11CACh. 22 - Describe the composition of semen. (p. 834)Ch. 22 - Prob. 13CACh. 22 - Prob. 14CACh. 22 - Prob. 15CACh. 22 - Distinguish between emission and ejaculation. (pp....Ch. 22 - Prob. 17CACh. 22 - Prob. 18CACh. 22 - Prob. 19CACh. 22 - Prob. 20CACh. 22 - Prob. 21CACh. 22 - Prob. 22CACh. 22 - Explain the regulation of testosterone secretion....Ch. 22 - Prob. 24CACh. 22 - Describe how the ovaries are held in position. (p....Ch. 22 - Prob. 26CACh. 22 - Prob. 27CACh. 22 - List the steps in oogenesis. (p. 841)Ch. 22 - Prob. 29CACh. 22 - Distinguish between a pre-antral and an antral...Ch. 22 - Prob. 31CACh. 22 - Prob. 32CACh. 22 - Prob. 33CACh. 22 - Prob. 34CACh. 22 - Prob. 35CACh. 22 - Prob. 36CACh. 22 - Prob. 37CACh. 22 - Prob. 38CACh. 22 - Prob. 39CACh. 22 - Prob. 40CACh. 22 - Prob. 41CACh. 22 - If left untreated, a complication of the diseases...Ch. 22 - Prob. 1IACh. 22 - Prob. 2IACh. 22 - Prob. 3IACh. 22 - Prob. 4IACh. 22 - As a male reaches adulthood, what will be the...Ch. 22 - Prob. 6IACh. 22 - Sometimes a sperm cell fertilizes a polar body...
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